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Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells

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Science Advances  08 May 2019:
Vol. 5, no. 5, eaau5240
DOI: 10.1126/sciadv.aau5240

Article Information

vol. 5 no. 5

Online ISSN: 
History: 
  • Received for publication June 19, 2018
  • Accepted for publication March 27, 2019
  • .

Author Information

  1. M. Feng1,*,
  2. J. Q. Jin2,*,
  3. L. Xia1,*,
  4. T. Xiao3,
  5. S. Mei4,
  6. X. Wang1,
  7. X. Huang1,
  8. J. Chen1,
  9. M. Liu2,
  10. C. Chen3,
  11. S. Rafi5,
  12. A. X. Zhu6,
  13. Y.-X. Feng7,8, and
  14. D. Zhu1,
  1. 1School of Pharmacy, Fudan University, Shanghai, 201203, China.
  2. 2Harvard College, Harvard University, Cambridge, MA 02138, USA.
  3. 3Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02145, USA.
  4. 4Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China.
  5. 5Schrödinger, LLC, Cambridge, MA 02142, USA.
  6. 6Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  7. 7The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Translational Medicine, Zhejiang University, Hangzhou 310029, China.
  8. 8Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  1. Corresponding author. Email: yxfeng{at}zju.edu.cn (Y.-X.F.); zhudi{at}fudan.edu.cn (D.Z.)
  • * These authors contributed equally to this work.

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