Research ArticleCANCER

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

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Science Advances  22 May 2019:
Vol. 5, no. 5, eaav3660
DOI: 10.1126/sciadv.aav3660

Article Information

vol. 5 no. 5

Online ISSN: 
History: 
  • Received for publication September 10, 2018
  • Accepted for publication April 17, 2019
  • .

Author Information

  1. Kenichi Iwai1,
  2. Tadahiro Nambu1,
  3. Ryo Dairiki1,
  4. Momoko Ohori1,
  5. Jie Yu2,
  6. Kristine Burke2,
  7. Masamitsu Gotou3,
  8. Yukiko Yamamoto1,
  9. Shunsuke Ebara1,
  10. Sachio Shibata1,
  11. Ryosuke Hibino1,
  12. Satoru Nishizawa1,
  13. Tohru Miyazaki1,
  14. Misaki Homma1,
  15. Yuya Oguro1,
  16. Takashi Imada1,
  17. Nobuo Cho1,
  18. Noriko Uchiyama4,
  19. Akifumi Kogame5,
  20. Toshiyuki Takeuchi5,
  21. Osamu Kurasawa1,
  22. Kazunori Yamanaka3,
  23. Huifeng Niu6 and
  24. Akihiro Ohashi1,2,7,*
  1. 1Oncology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  2. 2Oncology Drug Discovery Unit, Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
  3. 3Integrated Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  4. 4Biomolecular Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  5. 5DMPK Research Laboratories, Takeda Pharmaceutical Company Limited, Kanagawa, Japan.
  6. 6Translational and Biomarker Research, Takeda Pharmaceuticals International Co., Cambridge, MA, USA.
  7. 7Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.
  1. *Corresponding author. Email: aohashi{at}east.ncc.go.jp

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