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Electrospray sample injection for single-particle imaging with x-ray lasers

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Science Advances  03 May 2019:
Vol. 5, no. 5, eaav8801
DOI: 10.1126/sciadv.aav8801

Article Information

vol. 5 no. 5

Online ISSN: 
History: 
  • Received for publication October 30, 2018
  • Accepted for publication March 19, 2019
  • .

Author Information

  1. Johan Bielecki1,2,*,
  2. Max F. Hantke1,3,*,,
  3. Benedikt J. Daurer1,4,*,
  4. Hemanth K. N. Reddy1,
  5. Dirk Hasse1,
  6. Daniel S. D. Larsson1,
  7. Laura H. Gunn1,
  8. Martin Svenda1,5,
  9. Anna Munke1,
  10. Jonas A. Sellberg1,5,
  11. Leonie Flueckiger6,
  12. Alberto Pietrini1,
  13. Carl Nettelblad1,7,
  14. Ida Lundholm1,
  15. Gunilla Carlsson1,
  16. Kenta Okamoto1,
  17. Nicusor Timneanu1,8,
  18. Daniel Westphal1,
  19. Olena Kulyk9,
  20. Akifumi Higashiura10,11,
  21. Gijs van der Schot1,12,
  22. Ne-Te Duane Loh4,13,
  23. Taylor E. Wysong14,
  24. Christoph Bostedt15,16,
  25. Tais Gorkhover14,
  26. Bianca Iwan17,18,
  27. M. Marvin Seibert1,
  28. Timur Osipov14,
  29. Peter Walter14,
  30. Philip Hart14,
  31. Maximilian Bucher15,
  32. Anatoli Ulmer19,
  33. Dipanwita Ray14,
  34. Gabriella Carini14,,
  35. Ken R. Ferguson14,
  36. Inger Andersson1,
  37. Jakob Andreasson9,20,
  38. Janos Hajdu1,9 and
  39. Filipe R. N. C. Maia1,21,§
  1. 1Laboratory of Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3 (Box 596), SE-75124 Uppsala, Sweden.
  2. 2European XFEL GmbH, Holzkoppel 4, 22869 Schenefeld, Germany.
  3. 3Chemistry Research Laboratory, Department of Chemistry, Oxford University, 12 Mansfield Rd, Oxford OX1 3TA, UK.
  4. 4Centre for BioImaging Sciences, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117557, Singapore.
  5. 5Biomedical and X-ray Physics, Department of Applied Physics, AlbaNova University Center, KTH Royal Institute of Technology, SE-10691 Stockholm, Sweden.
  6. 6ARC Centre of Advanced Molecular Imaging, Department of Chemistry and Physics, La Trobe University, Melbourne, Victoria 3086, Australia.
  7. 7Division of Scientific Computing, Department of Information Technology, Science for Life Laboratory, Uppsala University, Lägerhyddsvägen 2 (Box 337), SE-751 05 Uppsala, Sweden.
  8. 8Department of Physics and Astronomy, Uppsala University, Box 516, SE-75120 Uppsala, Sweden.
  9. 9Institute of Physics, ELI Beamlines, Academy of Sciences of the Czech Republic, Na Slovance 2, CZ-18221 Prague, Czech Republic.
  10. 10Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan
  11. 11Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan
  12. 12Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, Netherlands
  13. 13Department of Physics, National University of Singapore, Singapore, Singapore.
  14. 14Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
  15. 15Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, IL 60439, USA.
  16. 16Department of Physics and Astronomy, Northwestern University, Evanston, IL 60208, USA.
  17. 17Stanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
  18. 18Institut für Quantenoptik, Leibniz Universität Hannover, Welfengarten 1, 30167 Hannover, Germany.
  19. 19Institut für Optik und Atomare Physik, Technische Universität Berlin, 10623 Berlin, Germany.
  20. 20Condensed Matter Physics, Department of Physics, Chalmers University of Technology, Gothenburg, Sweden.
  21. 21NERSC, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  1. §Corresponding author. Email: filipe{at}xray.bmc.uu.se
  • * These authors contributed equally to this work.

  • Present address: Refeyn Ltd., 33 George St, Oxford OX1 2AY, UK.

  • Present address: Brookhaven National Laboratory, Upton, NY 11973, USA.

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