Research ArticleBIOPHYSICS

Entropic effects enable life at extreme temperatures

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Science Advances  01 May 2019:
Vol. 5, no. 5, eaaw4783
DOI: 10.1126/sciadv.aaw4783

Article Information

vol. 5 no. 5

Online ISSN: 
  • Received for publication December 23, 2018
  • Accepted for publication March 14, 2019
  • .

Author Information

  1. Young Hun Kim1,*,
  2. Geoffray Leriche1,*,
  3. Karthik Diraviyam2,
  4. Takaoki Koyanagi1,
  5. Kaifu Gao3,
  6. David Onofrei4,
  7. Joseph Patterson1,
  8. Anirvan Guha5,
  9. Nathan Gianneschi6,
  10. Gregory P. Holland4,
  11. Michael K. Gilson3,
  12. Michael Mayer5,
  13. David Sept2 and
  14. Jerry Yang1,
  1. 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
  3. 3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  4. 4Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
  5. 5Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
  6. 6Departments of Chemistry, Materials Science and Engineering, and Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
  1. Corresponding author. Email: jerryyang{at}
  • * These authors contributed equally to this work.


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