Research ArticleBIOPHYSICS
Entropic effects enable life at extreme temperatures
- Young Hun Kim1,*,
- Geoffray Leriche1,*,
- Karthik Diraviyam2,
- Takaoki Koyanagi1,
- Kaifu Gao3,
- David Onofrei4,
- Joseph Patterson1,
- Anirvan Guha5,
- Nathan Gianneschi6,
- Gregory P. Holland4,
- Michael K. Gilson3,
- Michael Mayer5,
- David Sept2 and
- Jerry Yang1,†
- 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
- 2Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
- 3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
- 4Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
- 5Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
- 6Departments of Chemistry, Materials Science and Engineering, and Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
- ↵†Corresponding author. Email: jerryyang{at}ucsd.edu
↵* These authors contributed equally to this work.
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Science Advances 01 May 2019:
Vol. 5, no. 5, eaaw4783
DOI: 10.1126/sciadv.aaw4783
Vol. 5, no. 5, eaaw4783
DOI: 10.1126/sciadv.aaw4783
Young Hun Kim
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Geoffray Leriche
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Karthik Diraviyam
Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Takaoki Koyanagi
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Kaifu Gao
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
David Onofrei
Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Joseph Patterson
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Anirvan Guha
Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
Nathan Gianneschi
Departments of Chemistry, Materials Science and Engineering, and Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Gregory P. Holland
Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Michael K. Gilson
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Michael Mayer
Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
David Sept
Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Jerry Yang
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
