Research ArticleBIOPHYSICS
Entropic effects enable life at extreme temperatures
- View ORCID ProfileYoung Hun Kim1,*,
- Geoffray Leriche1,*,
- Karthik Diraviyam2,
- Takaoki Koyanagi1,
- View ORCID ProfileKaifu Gao3,
- David Onofrei4,
- Joseph Patterson1,
- View ORCID ProfileAnirvan Guha5,
- View ORCID ProfileNathan Gianneschi6,
- Gregory P. Holland4,
- View ORCID ProfileMichael K. Gilson3,
- View ORCID ProfileMichael Mayer5,
- View ORCID ProfileDavid Sept2 and
- View ORCID ProfileJerry Yang1,†
- 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
- 2Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
- 3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
- 4Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
- 5Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
- 6Departments of Chemistry, Materials Science and Engineering, and Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
- ↵†Corresponding author. Email: jerryyang{at}ucsd.edu
↵* These authors contributed equally to this work.
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Science Advances 01 May 2019:
Vol. 5, no. 5, eaaw4783
DOI: 10.1126/sciadv.aaw4783
Vol. 5, no. 5, eaaw4783
DOI: 10.1126/sciadv.aaw4783
Young Hun Kim
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Geoffray Leriche
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Karthik Diraviyam
2Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Takaoki Koyanagi
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Kaifu Gao
3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
David Onofrei
4Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Joseph Patterson
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
Anirvan Guha
5Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
Nathan Gianneschi
6Departments of Chemistry, Materials Science and Engineering, and Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
Gregory P. Holland
4Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
Michael K. Gilson
3Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Michael Mayer
5Adolphe Merkle Institute, University of Fribourg, Chemin des Verdiers 4, Fribourg, Switzerland.
David Sept
2Department of Biomedical Engineering, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Jerry Yang
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.
