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Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins

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Science Advances  19 Jun 2019:
Vol. 5, no. 6, eaax2650
DOI: 10.1126/sciadv.aax2650

Article Information

vol. 5 no. 6

Online ISSN: 
History: 
  • Received for publication March 7, 2019
  • Accepted for publication May 13, 2019
  • .

Author Information

  1. Tien-Jui Yen1,
  2. Marco Lolicato1,
  3. Rhiannon Thomas-Tran2,*,
  4. J. Du Bois2 and
  5. Daniel L. Minor Jr.1,3,4,5,6,
  1. 1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
  2. 2Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
  3. 3Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
  4. 4California Institute for Quantitative Biomedical Research, San Francisco, CA 94158, USA.
  5. 5Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA.
  6. 6Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  1. Corresponding author. Email: daniel.minor{at}ucsf.edu
  • * Present address: Gilead Sciences, 333 Lakeside Drive, Foster City, CA 94404, USA.

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