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Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain

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Science Advances  31 Jul 2019:
Vol. 5, no. 7, eaau4202
DOI: 10.1126/sciadv.aau4202

Article Information

vol. 5 no. 7

Online ISSN: 
History: 
  • Received for publication June 11, 2018
  • Accepted for publication June 26, 2019
  • .

Author Information

  1. Janna M. Bigalke1,*,
  2. Shintaro Aibara2,*,
  3. Robert Roth3,
  4. Göran Dahl1,
  5. Euan Gordon3,
  6. Sarah Dorbéus3,
  7. A. Amunts2,4, and
  8. Jenny Sandmark1,
  1. 1Structure, Biophysics and Fragment-Based Lead Generation, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  2. 2Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 17165 Solna, Sweden.
  3. 3Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.
  4. 4Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
  1. Corresponding author. Email: amunts{at}scilifelab.se (A.A.); jenny.sandmark{at}astrazeneca.com (J.S.)
  • * These authors contributed equally to this work.

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