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Research ArticleCELL BIOLOGY
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7
- View ORCID ProfileScott McComb1,*,
- View ORCID ProfilePik Ki Chan1,*,
- View ORCID ProfileAnna Guinot1,*,
- View ORCID ProfileHolmfridur Hartmannsdottir1,
- Silvia Jenni1,
- Maria Pamela Dobay1,2,
- Jean-Pierre Bourquin1 and
- View ORCID ProfileBeat C. Bornhauser1,†
- 1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
- 2IQVIA Technology and Services AG Theaterstrasse 4, 4051 Basel, Switzerland.
- ↵†Corresponding author. Email: beat.bornhauser{at}kispi.uzh.ch
↵* These authors contributed equally to this work.
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Science Advances 31 Jul 2019:
Vol. 5, no. 7, eaau9433
DOI: 10.1126/sciadv.aau9433
Vol. 5, no. 7, eaau9433
DOI: 10.1126/sciadv.aau9433
Scott McComb
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
Pik Ki Chan
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
Anna Guinot
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
Holmfridur Hartmannsdottir
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
Silvia Jenni
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
Maria Pamela Dobay
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
2IQVIA Technology and Services AG Theaterstrasse 4, 4051 Basel, Switzerland.
Jean-Pierre Bourquin
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
Beat C. Bornhauser
1Department of Oncology and Children’s Research Centre, University Children’s Hospital Zürich, 8032 Zürich, Switzerland.
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