Research ArticleCELL BIOLOGY

Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis

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Science Advances  17 Jul 2019:
Vol. 5, no. 7, eaav3270
DOI: 10.1126/sciadv.aav3270

Article Information

vol. 5 no. 7

Online ISSN: 
History: 
  • Received for publication September 6, 2018
  • Accepted for publication June 11, 2019
  • .

Author Information

  1. Diantha van de Vlekkert1,
  2. Jeroen Demmers2,
  3. Xinh-Xinh Nguyen3,
  4. Yvan Campos1,
  5. Eda Machado1,
  6. Ida Annunziata1,
  7. Huimin Hu1,
  8. Elida Gomero1,
  9. Xiaohui Qiu1,
  10. Antonella Bongiovanni4,
  11. Carol A. Feghali-Bostwick3 and
  12. Alessandra d’Azzo1,5,*
  1. 1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
  2. 2Proteomics Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, Netherlands.
  3. 3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  4. 4Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.
  5. 5Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  1. *Corresponding author. Email: sandra.dazzo{at}stjude.org

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