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Research ArticleCELL BIOLOGY
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis
- View ORCID ProfileDiantha van de Vlekkert1,
- View ORCID ProfileJeroen Demmers2,
- Xinh-Xinh Nguyen3,
- Yvan Campos1,
- View ORCID ProfileEda Machado1,
- Ida Annunziata1,
- Huimin Hu1,
- View ORCID ProfileElida Gomero1,
- Xiaohui Qiu1,
- View ORCID ProfileAntonella Bongiovanni4,
- View ORCID ProfileCarol A. Feghali-Bostwick3 and
- View ORCID ProfileAlessandra d’Azzo1,5,*
- 1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
- 2Proteomics Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, Netherlands.
- 3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
- 4Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.
- 5Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
- ↵*Corresponding author. Email: sandra.dazzo{at}stjude.org
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Science Advances 17 Jul 2019:
Vol. 5, no. 7, eaav3270
DOI: 10.1126/sciadv.aav3270
Vol. 5, no. 7, eaav3270
DOI: 10.1126/sciadv.aav3270
Diantha van de Vlekkert
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Jeroen Demmers
2Proteomics Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, Netherlands.
Xinh-Xinh Nguyen
3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Yvan Campos
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Eda Machado
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Ida Annunziata
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Huimin Hu
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Elida Gomero
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Xiaohui Qiu
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Antonella Bongiovanni
4Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.
Carol A. Feghali-Bostwick
3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Alessandra d’Azzo
1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
5Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.
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