Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis

Diantha van de Vlekkert; Jeroen Demmers; Xinh-Xinh Nguyen; Yvan Campos; Eda Machado; Ida Annunziata; Huimin Hu; Elida Gomero; Xiaohui Qiu; Antonella Bongiovanni; Carol A. Feghali-Bostwick; Alessandra d’Azzo

doi:10.1126/sciadv.aav3270

Research ArticleCELL BIOLOGY

Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis

View ORCID ProfileDiantha van de Vlekkert¹,
View ORCID ProfileJeroen Demmers²,
Xinh-Xinh Nguyen³,
Yvan Campos¹,
View ORCID ProfileEda Machado¹,
Ida Annunziata¹,
Huimin Hu¹,
View ORCID ProfileElida Gomero¹,
Xiaohui Qiu¹,
View ORCID ProfileAntonella Bongiovanni⁴,
View ORCID ProfileCarol A. Feghali-Bostwick³ and
View ORCID ProfileAlessandra d’Azzo ¹,⁵,*

¹Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
²Proteomics Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, Netherlands.
³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
⁴Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.
⁵Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

↵*Corresponding author. Email: sandra.dazzo{at}stjude.org

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Science Advances 17 Jul 2019:
Vol. 5, no. 7, eaav3270
DOI: 10.1126/sciadv.aav3270

Diantha van de Vlekkert

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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ORCID record for Diantha van de Vlekkert

Jeroen Demmers

2Proteomics Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, Netherlands.

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Xinh-Xinh Nguyen

3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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Yvan Campos

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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Eda Machado

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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ORCID record for Eda Machado

Ida Annunziata

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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Huimin Hu

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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Elida Gomero

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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ORCID record for Elida Gomero

Xiaohui Qiu

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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Antonella Bongiovanni

4Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR) of Italy, Palermo, Italy.

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Carol A. Feghali-Bostwick

3Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.

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Alessandra d’Azzo

1Department of Genetics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

5Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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ORCID record for Alessandra d’Azzo
For correspondence: sandra.dazzo@stjude.org

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Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis

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