Research ArticleHEALTH AND MEDICINE

Covalent chemistry on nanostructured substrates enables noninvasive quantification of gene rearrangements in circulating tumor cells

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Science Advances  31 Jul 2019:
Vol. 5, no. 7, eaav9186
DOI: 10.1126/sciadv.aav9186

Article Information

vol. 5 no. 7

Online ISSN: 
History: 
  • Received for publication November 7, 2018
  • Accepted for publication June 26, 2019
  • .

Author Information

  1. Jiantong Dong1,2,
  2. Yu Jen Jan1,3,
  3. Ju Cheng1,
  4. Ryan Y. Zhang1,
  5. Meng Meng1,4,
  6. Matthew Smalley1,
  7. Pin-Jung Chen1,3,
  8. Xinghong Tang1,
  9. Patrick Tseng1,
  10. Lirong Bao1,
  11. Tzu-Yang Huang5,
  12. Dongjing Zhou6,
  13. Yupin Liu6,
  14. Xiaoshu Chai6,
  15. Haibo Zhang6,
  16. Anqi Zhou1,
  17. Vatche G. Agopian7,
  18. Edwin M. Posadas3,
  19. Jing-Jong Shyue8,
  20. Steven J. Jonas9,
  21. Paul S. Weiss10,
  22. Mengyuan Li2,*,
  23. Guangjuan Zheng6,*,
  24. Hsiao-hua Yu5,*,
  25. Meiping Zhao2,*,
  26. Hsian-Rong Tseng1,* and
  27. Yazhen Zhu1,*
  1. 1California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  2. 2Beijing National Laboratory for Molecular Sciences, MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
  3. 3Urologic Oncology Program and Uro-Oncology Research Laboratories, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  4. 4State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China.
  5. 5Smart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan.
  6. 6Department of Pathology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China.
  7. 7Department of Surgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  8. 8Research Center for Applied Sciences, Academia Sinica, Taipei 11529, Taiwan.
  9. 9Department of Pediatrics, David Geffen School of Medicine, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and Children’s Discovery and Innovation Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  10. 10California NanoSystems Institute, Departments of Chemistry and Biochemistry and Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  1. *Corresponding author. Email: hrtseng{at}mednet.ucla.edu (H.-R.T.); yazhenzhu{at}mednet.ucla.edu (Y.Z.); mpzhao{at}pku.edu.cn (M.Z.); bruceyu{at}gate.sinica.edu.tw (H.-h.Y.); zhengguangjuan{at}163.com (G.Z.); mengyuanli{at}pku.edu.cn (M.L.).

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