Research ArticleHEALTH AND MEDICINE

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

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Science Advances  10 Jul 2019:
Vol. 5, no. 7, eaaw4357
DOI: 10.1126/sciadv.aaw4357

Article Information

vol. 5 no. 7

Online ISSN: 
History: 
  • Received for publication December 19, 2018
  • Accepted for publication June 6, 2019
  • .

Author Information

  1. Jinqiang Wang1,2,3,*,
  2. Jicheng Yu3,*,
  3. Yuqi Zhang3,
  4. Xudong Zhang1,2,
  5. Anna R. Kahkoska4,
  6. Guojun Chen1,2,
  7. Zejun Wang1,2,
  8. Wujin Sun1,5,
  9. Lulu Cai1,2,6,
  10. Zhaowei Chen3,
  11. Chenggen Qian7,
  12. Qundong Shen7,
  13. Ali Khademhosseini1,2,5,8,9,
  14. John B. Buse4 and
  15. Zhen Gu1,2,3,5,10,
  1. 1Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
  2. 2California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
  3. 3Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA.
  4. 4Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  5. 5Center for Minimally Invasive Therapeutics, University of California, Los Angeles, Los Angeles, CA, USA.
  6. 6Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Provincial People's Hospital, University of Electronic, Science and Technology of China, Chengdu 611731, China.
  7. 7Department of Polymer Science and Engineering and Key Laboratory of High-Performance Polymer Materials and Technology of MOE, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
  8. 8Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.
  9. 9Department of Radiology, University of California, Los Angeles, Los Angeles, CA, USA.
  10. 10Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
  1. Corresponding author. Email: guzhen{at}ucla.edu
  • * These authors contributed equally to this work.

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