Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves

Yi Zhang; Aaron D. Mickle; Philipp Gutruf; Lisa A. McIlvried; Hexia Guo; Yixin Wu; Judith P. Golden; Yeguang Xue; Jose G. Grajales-Reyes; Xueju Wang; Siddharth Krishnan; Yiwen Xie; Dongsheng Peng; Chun-Ju Su; Fengyi Zhang; Jonathan T. Reeder; Sherri K. Vogt; Yonggang Huang; John A. Rogers; Robert W. Gereau

doi:10.1126/sciadv.aaw5296

Research ArticleENGINEERING

Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves

Yi Zhang¹,²,*,
Aaron D. Mickle ³,⁴,*,
Philipp Gutruf⁵,²,*,
Lisa A. McIlvried³,⁴,*,
Hexia Guo²,
Yixin Wu²,
Judith P. Golden³,⁴,
Yeguang Xue⁶,⁷,
Jose G. Grajales-Reyes ³,⁴,
Xueju Wang⁸,
Siddharth Krishnan²,
Yiwen Xie²,
Dongsheng Peng²,⁹,
Chun-Ju Su²,
Fengyi Zhang¹⁰,
Jonathan T. Reeder²,
Sherri K. Vogt³,⁴,
Yonggang Huang²,⁶,⁷,
John A. Rogers²,¹¹,¹²,¹³,¹⁴,¹⁵,† and
Robert W. Gereau IV ³,⁴,¹⁶,†

¹Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211, USA.
²Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.
³Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.
⁴Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.
⁵Biomedical Engineering, College of Engineering, The University of Arizona, Bioscience Research Laboratories, 1230 N. Cherry Ave., Tucson, AZ 85721, USA.
⁶Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
⁷Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
⁸Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.
⁹College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
¹⁰School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA.
¹¹Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.
¹²Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
¹³Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
¹⁴Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
¹⁵Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
¹⁶Departments of Neuroscience and Biomedical Engineering, Washington University, St. Louis, MO 63110, USA.

↵†Corresponding author. Email: jrogers{at}northwestern.edu (J.A.R.); gereaur{at}wustl.edu (R.W.G.)

↵* These authors contributed equally to this work.

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Science Advances 05 Jul 2019:
Vol. 5, no. 7, eaaw5296
DOI: 10.1126/sciadv.aaw5296

Yi Zhang

1Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211, USA.

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Aaron D. Mickle

3Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

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Philipp Gutruf

5Biomedical Engineering, College of Engineering, The University of Arizona, Bioscience Research Laboratories, 1230 N. Cherry Ave., Tucson, AZ 85721, USA.

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Lisa A. McIlvried

3Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

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Hexia Guo

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Yixin Wu

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Judith P. Golden

3Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

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Yeguang Xue

6Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

7Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

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Jose G. Grajales-Reyes

3Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

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Xueju Wang

8Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211, USA.

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Siddharth Krishnan

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Yiwen Xie

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Dongsheng Peng

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

9College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

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Chun-Ju Su

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Fengyi Zhang

10School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30318, USA.

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Jonathan T. Reeder

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

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Sherri K. Vogt

3Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

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Yonggang Huang

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

6Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.

7Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.

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John A. Rogers

2Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208, USA.

11Simpson Querrey Institute, Northwestern University, Chicago, IL 60611, USA.

12Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.

13Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.

14Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.

15Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

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For correspondence: jrogers@northwestern.edu gereaur@wustl.edu

Robert W. Gereau IV

3Washington University Pain Center and Department of Anesthesiology, Washington University, St. Louis, MO 63110, USA.

4Washington University School of Medicine, 660 S. Euclid Ave., Box 8054, St. Louis, MO 63110, USA.

16Departments of Neuroscience and Biomedical Engineering, Washington University, St. Louis, MO 63110, USA.

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For correspondence: jrogers@northwestern.edu gereaur@wustl.edu

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Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves

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