Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

Runchen Zhao; Alexandros Afthinos; Tian Zhu; Panagiotis Mistriotis; Yizeng Li; Selma A. Serra; Yuqi Zhang; Christopher L. Yankaskas; Shuyu He; Miguel A. Valverde; Sean X. Sun; Konstantinos Konstantopoulos

doi:10.1126/sciadv.aaw7243

Research ArticleCELL BIOLOGY

Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

View ORCID ProfileRunchen Zhao¹,²,*,
View ORCID ProfileAlexandros Afthinos¹,²,*,
View ORCID ProfileTian Zhu¹,²,
View ORCID ProfilePanagiotis Mistriotis¹,²,
View ORCID ProfileYizeng Li²,³,
View ORCID ProfileSelma A. Serra⁴,
View ORCID ProfileYuqi Zhang¹,²,
View ORCID ProfileChristopher L. Yankaskas¹,²,
View ORCID ProfileShuyu He¹,
View ORCID ProfileMiguel A. Valverde⁴,
View ORCID ProfileSean X. Sun ¹,²,³,⁵,⁶ and
View ORCID ProfileKonstantinos Konstantopoulos ¹,²,⁵,⁶,⁷,†

¹Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
²Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
³Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
⁴Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
⁵Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.
⁶Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
⁷Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA.

↵†Corresponding author. Email: konstant{at}jhu.edu

↵* These authors contributed equally to this work.

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Science Advances 24 Jul 2019:
Vol. 5, no. 7, eaaw7243
DOI: 10.1126/sciadv.aaw7243

Runchen Zhao

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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ORCID record for Runchen Zhao

Alexandros Afthinos

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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Tian Zhu

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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Panagiotis Mistriotis

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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Yizeng Li

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

3Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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Selma A. Serra

4Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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ORCID record for Selma A. Serra

Yuqi Zhang

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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Christopher L. Yankaskas

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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Shuyu He

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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Miguel A. Valverde

4Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

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Sean X. Sun

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

3Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

5Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.

6Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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Konstantinos Konstantopoulos

1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

2Johns Hopkins Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

5Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.

6Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

7Department of Oncology, Johns Hopkins University, Baltimore, MD 21205, USA.

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ORCID record for Konstantinos Konstantopoulos
For correspondence: konstant@jhu.edu

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