CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

Andrea Piunti; Edwin R. Smith; Marc A. J. Morgan; Michal Ugarenko; Natalia Khaltyan; Kathryn A. Helmin; Caila A. Ryan; David C. Murray; Ryan A. Rickels; Bahar D. Yilmaz; Emily J. Rendleman; Jeffrey N. Savas; Benjamin D. Singer; Serdar E. Bulun; Ali Shilatifard

doi:10.1126/sciadv.aax2887

Research ArticleBIOCHEMISTRY

CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

View ORCID ProfileAndrea Piunti¹,²,
View ORCID ProfileEdwin R. Smith¹,²,
View ORCID ProfileMarc A. J. Morgan¹,²,
View ORCID ProfileMichal Ugarenko¹,²,
Natalia Khaltyan³,
Kathryn A. Helmin⁴,
Caila A. Ryan¹,²,
David C. Murray²,
Ryan A. Rickels¹,²,
View ORCID ProfileBahar D. Yilmaz⁵,
View ORCID ProfileEmily J. Rendleman¹,²,
View ORCID ProfileJeffrey N. Savas³,
View ORCID ProfileBenjamin D. Singer¹,²,⁴,
Serdar E. Bulun⁵ and
View ORCID ProfileAli Shilatifard¹,²,*

¹Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.
²Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.
³Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.
⁴Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.
⁵Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

↵*Corresponding author. Email: ash{at}northwestern.edu

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Science Advances 03 Jul 2019:
Vol. 5, no. 7, eaax2887
DOI: 10.1126/sciadv.aax2887

Andrea Piunti

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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ORCID record for Andrea Piunti

Edwin R. Smith

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Marc A. J. Morgan

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Michal Ugarenko

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Natalia Khaltyan

3Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Kathryn A. Helmin

4Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Caila A. Ryan

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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David C. Murray

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Ryan A. Rickels

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Bahar D. Yilmaz

5Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Emily J. Rendleman

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Jeffrey N. Savas

3Department of Neurology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Benjamin D. Singer

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

4Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Serdar E. Bulun

5Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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Ali Shilatifard

1Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

2Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 East Superior Street, Chicago, IL 60611, USA.

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For correspondence: ash@northwestern.edu

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CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism

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