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BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS

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Science Advances  14 Aug 2019:
Vol. 5, no. 8, eaav8463
DOI: 10.1126/sciadv.aav8463

Article Information

vol. 5 no. 8

Online ISSN: 
  • Received for publication October 25, 2018
  • Accepted for publication July 9, 2019
  • .

Author Information

  1. Ruth Röck1,*,
  2. Johanna E. Mayrhofer1,*,
  3. Omar Torres-Quesada1,
  4. Florian Enzler1,
  5. Andrea Raffeiner1,
  6. Philipp Raffeiner1,,
  7. Andreas Feichtner1,
  8. Roland G. Huber2,
  9. Shohei Koide3,
  10. Susan S. Taylor4,
  11. Jakob Troppmair5 and
  12. Eduard Stefan1,
  1. 1Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
  2. 2Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore 138671, Singapore.
  3. 3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine and Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
  4. 4Department of Pharmacology, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California, San Diego, San Diego, CA 92093, USA.
  5. 5Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innrain 66, 6020 Innsbruck, Austria.
  1. Corresponding author. Email: eduard.stefan{at}
  • * These authors contributed equally to this work.

  • Present address: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.


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