Research ArticleBIOCHEMISTRY
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS
- Ruth Röck1,*,
- Johanna E. Mayrhofer1,*,
- Omar Torres-Quesada1,
- Florian Enzler1,
- Andrea Raffeiner1,
- Philipp Raffeiner1,†,
- Andreas Feichtner1,
- Roland G. Huber2,
- Shohei Koide3,
- Susan S. Taylor4,
- Jakob Troppmair5 and
- Eduard Stefan1,‡
- 1Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
- 2Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore 138671, Singapore.
- 3Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine and Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
- 4Department of Pharmacology, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California, San Diego, San Diego, CA 92093, USA.
- 5Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innrain 66, 6020 Innsbruck, Austria.
- ↵‡Corresponding author. Email: eduard.stefan{at}uibk.ac.at
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Science Advances 14 Aug 2019:
Vol. 5, no. 8, eaav8463
DOI: 10.1126/sciadv.aav8463
Vol. 5, no. 8, eaav8463
DOI: 10.1126/sciadv.aav8463
Ruth Röck
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Johanna E. Mayrhofer
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Omar Torres-Quesada
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Florian Enzler
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Andrea Raffeiner
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Philipp Raffeiner
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Andreas Feichtner
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
Roland G. Huber
Bioinformatics Institute (BII), Agency for Science Technology and Research (A*STAR), Singapore 138671, Singapore.
Shohei Koide
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine and Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
Susan S. Taylor
Department of Pharmacology, Department of Chemistry and Biochemistry, and Howard Hughes Medical Institute, University of California, San Diego, San Diego, CA 92093, USA.
Jakob Troppmair
Daniel Swarovski Research Laboratory, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innrain 66, 6020 Innsbruck, Austria.
Eduard Stefan
Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.
