Research ArticleIMMUNOLOGY

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

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Science Advances  21 Aug 2019:
Vol. 5, no. 8, eaaw8330
DOI: 10.1126/sciadv.aaw8330

Article Information

vol. 5 no. 8

Online ISSN: 
  • Received for publication January 30, 2019
  • Accepted for publication July 12, 2019
  • .

Author Information

  1. Yehezqel Elyahu1,2,3,*,
  2. Idan Hekselman3,4,*,
  3. Inbal Eizenberg-Magar5,
  4. Omer Berner1,2,3,
  5. Itai Strominger1,2,3,
  6. Maya Schiller6,
  7. Kritika Mittal1,2,3,
  8. Anna Nemirovsky1,2,3,
  9. Ekaterina Eremenko1,2,3,
  10. Assaf Vital3,4,
  11. Eyal Simonovsky3,4,
  12. Vered Chalifa-Caspi3,
  13. Nir Friedman5,
  14. Esti Yeger-Lotem3,4, and
  15. Alon Monsonego1,2,3,
  1. 1The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
  2. 2Zlotowski Neuroscience Center and Regenerative Medicine and Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
  3. 3National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
  4. 4Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
  5. 5Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
  6. 6Departments of Immunology and Neuroscience, Rappaport Faculty of Medicine, and the Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3525422, Israel.
  1. Corresponding author. Email: alonmon{at} (A.M.); estiyl{at} (E.Y.-L.)
  • * These authors contributed equally to this work.


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