Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Yehezqel Elyahu; Idan Hekselman; Inbal Eizenberg-Magar; Omer Berner; Itai Strominger; Maya Schiller; Kritika Mittal; Anna Nemirovsky; Ekaterina Eremenko; Assaf Vital; Eyal Simonovsky; Vered Chalifa-Caspi; Nir Friedman; Esti Yeger-Lotem; Alon Monsonego

doi:10.1126/sciadv.aaw8330

Research ArticleIMMUNOLOGY

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Yehezqel Elyahu¹,²,³,*,
Idan Hekselman³,⁴,*,
Inbal Eizenberg-Magar⁵,
Omer Berner¹,²,³,
Itai Strominger¹,²,³,
Maya Schiller⁶,
Kritika Mittal¹,²,³,
Anna Nemirovsky¹,²,³,
Ekaterina Eremenko¹,²,³,
Assaf Vital³,⁴,
Eyal Simonovsky³,⁴,
Vered Chalifa-Caspi³,
Nir Friedman⁵,
Esti Yeger-Lotem³,⁴,† and
Alon Monsonego ¹,²,³,†

¹The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.
²Zlotowski Neuroscience Center and Regenerative Medicine and Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
³National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁴Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
⁵Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.
⁶Departments of Immunology and Neuroscience, Rappaport Faculty of Medicine, and the Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3525422, Israel.

↵†Corresponding author. Email: alonmon{at}bgu.ac.il (A.M.); estiyl{at}bgu.ac.il (E.Y.-L.)

↵* These authors contributed equally to this work.

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Science Advances 21 Aug 2019:
Vol. 5, no. 8, eaaw8330
DOI: 10.1126/sciadv.aaw8330

Yehezqel Elyahu

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.Zlotowski Neuroscience Center and Regenerative Medicine and Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Idan Hekselman

National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Inbal Eizenberg-Magar

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

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Omer Berner

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Itai Strominger

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Maya Schiller

Departments of Immunology and Neuroscience, Rappaport Faculty of Medicine, and the Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3525422, Israel.

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Kritika Mittal

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Anna Nemirovsky

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Ekaterina Eremenko

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Assaf Vital

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Eyal Simonovsky

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Vered Chalifa-Caspi

National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

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Nir Friedman

Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

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Esti Yeger-Lotem

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For correspondence: alonmon@bgu.ac.il estiyl@bgu.ac.il

Alon Monsonego

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For correspondence: alonmon@bgu.ac.il estiyl@bgu.ac.il

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Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

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