Research ArticleBIOPHYSICS

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

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Science Advances  28 Aug 2019:
Vol. 5, no. 8, eaaw9298
DOI: 10.1126/sciadv.aaw9298

Article Information

vol. 5 no. 8

Online ISSN: 
History: 
  • Received for publication February 6, 2019
  • Accepted for publication July 16, 2019
  • .

Author Information

  1. Caitlin Walker1,
  2. Yingjie Wang1,2,
  3. Cristina Olivieri1,
  4. Adak Karamafrooz1,
  5. Jordan Casby1,
  6. Kerstin Bathon3,
  7. Davide Calebiro4,5,
  8. Jiali Gao2,6,
  9. David A. Bernlohr1,
  10. Susan S. Taylor7 and
  11. Gianluigi Veglia1,2,*
  1. 1Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
  2. 2Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
  3. 3Institute for Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany.
  4. 4Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.
  5. 5Centre of Membrane Proteins and Receptors, University of Birmingham, Birmingham B15 2TT, UK.
  6. 6Shenzhen Bay Laboratory and Laboratory of Computational Chemistry and Drug Design, Peking University Graduate School, Shenzhen 518055, China.
  7. 7Departments of Chemistry and Biochemistry and Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.
  1. *Corresponding author. Email: vegli001{at}umn.edu

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