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Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer–mediated autoimmune diabetes

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Science Advances  21 Aug 2019:
Vol. 5, no. 8, eaaw9336
DOI: 10.1126/sciadv.aaw9336

Article Information

vol. 5 no. 8

Online ISSN: 
History: 
  • Received for publication February 7, 2019
  • Accepted for publication July 11, 2019
  • .

Author Information

  1. I-Ting Chow1,
  2. Theresa J. Gates1,
  3. George K. Papadopoulos2,*,
  4. Antonis K. Moustakas3,
  5. Elizabeth M. Kolawole4,
  6. Richard J. Notturno1,
  7. John W. McGinty1,
  8. Nadia Torres-Chinn1,
  9. Eddie A. James1,
  10. Carla Greenbaum1,
  11. Gerald T. Nepom1,5,
  12. Brian D. Evavold4 and
  13. William W. Kwok1,6,
  1. 1Benaroya Research Institute at Virginia Mason, 1201 9th Ave., Seattle, WA 98101, USA.
  2. 2Laboratory of Biophysics, Biochemistry, Bioprocessing and Bioproducts, Faculty of Agricultural Technology, Technological Educational Institute of Epirus, GR47100 Arta, Greece.
  3. 3Department of Food Technology, Ionian University, GR28100 Argostoli, Cephallonia, Greece.
  4. 4Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
  5. 5Department of Immunology, University of Washington, Seattle, WA 98195, USA.
  6. 6Department of Medicine, University of Washington, Seattle, WA 98195, USA.
  1. Corresponding author. Email: bkwok{at}benaroyaresearch.org
  • * Laboratory address given for identification purposes only. G.K.P. has retired as of 31 August 2018. Since 1 October 2018, the Technological Educational Institute of Epirus has been absorbed by the University of Ioannina with the respective department’s name changed to Department of Agriculture.

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