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Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing

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Science Advances  28 Aug 2019:
Vol. 5, no. 8, eaax0801
DOI: 10.1126/sciadv.aax0801

Article Information

vol. 5 no. 8

Online ISSN: 
History: 
  • Received for publication February 20, 2019
  • Accepted for publication July 19, 2019
  • .

Author Information

  1. Minh Khanh Nguyen1,*,
  2. Cong Truc Huynh1,*,,
  3. Alex Gilewski1,*,,
  4. Samantha E. Wilner2,§,
  5. Keith E. Maier2,||,
  6. Nicholas Kwon1,
  7. Mathew Levy2,3, and
  8. Eben Alsberg1,4,,
  1. 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
  2. 2Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  3. 3Vitrisa Therapeutics Inc., 701 W Main St. Suite 200, Durham, NC 27701, USA.
  4. 4Department of Orthopaedic Surgery, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
  1. Corresponding author. Email: matthew.levy{at}einstein.yu.edu (M.L.); ealsberg{at}uic.edu (E.A.)
  • * These authors contributed equally to this work.

  • Present address: Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, USA.

  • Present address: Department of Chemistry, Glendale Community College, 1500 N Verdugo Rd., Glendale, CA 91208, USA.

  • § Present address: Department of Chemistry, Ursinus College, 601 E. Main Street, Collegeville, PA 19426, USA.

  • || Present address: EpiCypher Inc., 6 Davis Drive, Durham, NC 27709, USA.

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