Research ArticleMICROBIOLOGY

Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity

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Science Advances  07 Aug 2019:
Vol. 5, no. 8, eaax2358
DOI: 10.1126/sciadv.aax2358

Article Information

vol. 5 no. 8

Online ISSN: 
History: 
  • Received for publication March 5, 2019
  • Accepted for publication June 28, 2019
  • .

Author Information

  1. Michael R. Taylor1,2,3,
  2. Kyle L. Flannigan4,5,
  3. Hannah Rahim1,2,3,
  4. Amina Mohamud1,2,3,
  5. Ian A. Lewis6,
  6. Simon A. Hirota4,5,7 and
  7. Steven C. Greenway1,2,3,8,*
  1. 1Departments of Pediatrics and Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  2. 2Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  3. 3Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  4. 4Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  5. 5Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  6. 6Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
  7. 7Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  8. 8Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  1. *Corresponding author. Email: scgreenw{at}ucalgary.ca

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