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Deconvolution of transcriptional networks identifies TCF4 as a master regulator in schizophrenia

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Science Advances  11 Sep 2019:
Vol. 5, no. 9, eaau4139
DOI: 10.1126/sciadv.aau4139

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication June 7, 2018
  • Accepted for publication August 8, 2019
  • .

Author Information

  1. Abolfazl Doostparast Torshizi1,2,
  2. Chris Armoskus3,4,
  3. Hanwen Zhang5,
  4. Marc P. Forrest6,7,
  5. Siwei Zhang5,8,
  6. Tade Souaiaia3,4,
  7. Oleg V. Evgrafov3,4,
  8. James A. Knowles3,4,
  9. Jubao Duan5,8,* and
  10. Kai Wang1,2,4,*
  1. 1Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  2. 2Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3College of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
  4. 4Zilkhe Neurogenetic Institute, University of Southern California, Los Angeles, CA 90089, USA.
  5. 5Center for Psychiatric Genetics, North Shore University Health System, Evanston, IL 60201, USA.
  6. 6Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  7. 7Center for Autism and Neurodevelopment, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
  8. 8Department of Psychiatry and Behavioral Neurosciences, University of Chicago, Chicago, IL 60015, USA.
  1. *Corresponding author. Email: jduan{at}uchicago.edu (J.D.); wangk{at}email.chop.edu (K.W.)

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