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Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics

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Science Advances  13 Sep 2019:
Vol. 5, no. 9, eaaw0672
DOI: 10.1126/sciadv.aaw0672

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication November 14, 2018
  • Accepted for publication August 15, 2019
  • .

Author Information

  1. Rui Tian1,*,
  2. Qiao Zeng2,*,
  3. Shoujun Zhu1,,,
  4. Joseph Lau1,
  5. Swati Chandra1,
  6. Robert Ertsey3,
  7. Kenneth S. Hettie3,§,
  8. Tarn Teraphongphom3,
  9. Zhubin Hu4,
  10. Gang Niu1,
  11. Dale O. Kiesewetter1,
  12. Haitao Sun4,,
  13. Xiaodong Zhang5,
  14. Alexander L. Antaris6,
  15. Bernard R. Brooks2 and
  16. Xiaoyuan Chen1,
  1. 1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA.
  2. 2Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
  3. 3Department of Otolaryngology, Stanford University, Stanford, CA 94305, USA.
  4. 4State Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai 200062, P. R. China.
  5. 5Department of Physics, School of Science, Tianjin University, Tianjin 300354, P. R. China.
  6. 6Intuitive Surgical, Kifer Rd., Sunnyvale, CA 94086, USA.
  1. Corresponding author. Email: sjzhu{at}jlu.edu.cn (S.Z.); shawn.chen{at}nih.gov (X.C.); htsun{at}phy.ecnu.edu.cn (H.S.)
  • * These authors contributed equally to this work.

  • Present address: Institute of Translational Medicine, The First Hospital; State Key Laboratory of Supramolecular Structure and Materials College of Chemistry, Jilin University, Changchun 130021, China.

  • § Present address: Department of Radiology, Stanford University, Stanford, CA 94305, USA.

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