Research ArticleSTRUCTURAL BIOLOGY

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

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Science Advances  25 Sep 2019:
Vol. 5, no. 9, eaaw2853
DOI: 10.1126/sciadv.aaw2853

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication December 5, 2018
  • Accepted for publication August 21, 2019
  • .

Author Information

  1. Charles Vragniau1,*,
  2. Joshua C. Bufton2,*,
  3. Frédéric Garzoni3,
  4. Emilie Stermann1,
  5. Fruzsina Rabi2,
  6. Céline Terrat4,
  7. Mélanie Guidetti5,
  8. Véronique Josserand5,
  9. Matt Williams6,
  10. Christopher J. Woods6,
  11. Gerardo Viedma7,
  12. Phil Bates7,
  13. Bernard Verrier4,
  14. Laurence Chaperot8,
  15. Christiane Schaffitzel2,,
  16. Imre Berger2,9, and
  17. Pascal Fender1,
  1. 1Institut de Biologie Structurale (IBS), Université Grenoble Alpes, CNRS, CEA, 71 Avenue des Martyrs, 38042 Grenoble, France.
  2. 2Bristol Research Centre for Synthetic Biology BrisSynBio, School of Biochemistry, University of Bristol, 1 Tankard’s Close, Bristol BS8 1TD, UK.
  3. 3Imophoron Ltd., Unit DX, St. Philips Central, Albert Road, Bristol BS2 OXJ, UK.
  4. 4Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique (LBTI), UMR 5305, Université Lyon 1, CNRS, Institut de Biologie et Chimie des Protéines (IBCP), Lyon, France.
  5. 5Cancer Target and Experimental Therapeutics, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, 38700 Grenoble, France.
  6. 6Advanced Computing Research Centre, University of Bristol, 31 Great George Street, Bristol BS1 5QD, UK.
  7. 7Oracle Cloud Development Centre, Tower Wharf, Cheese Lane, Bristol BS2 2JJ, UK.
  8. 8Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Etablissement Français du Sang-Rhone-Alpes, 38700 Grenoble, France.
  9. 9Max Planck-Bristol Centre for Minimal Biology, Cantock’s Close, Bristol BS8 1TS, UK.
  1. Corresponding author. Email: pascal.fender{at}ibs.fr (P.F.); imre.berger{at}bristol.ac.uk (I.B.); cb14941{at}bristol.ac.uk (C.S.)
  • * These authors contributed equally to this work.

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