Research ArticleHUMAN GENETICS

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

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Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaaw3095
DOI: 10.1126/sciadv.aaw3095

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication December 7, 2018
  • Accepted for publication August 6, 2019
  • .

Author Information

  1. Alexessander Couto Alves1,2,*,
  2. N. Maneka G. De Silva1,*,
  3. Ville Karhunen1,
  4. Ulla Sovio3,4,
  5. Shikta Das1,5,
  6. H. Rob Taal6,7,
  7. Nicole M. Warrington8,9,
  8. Alexandra M. Lewin1,10,
  9. Marika Kaakinen11,12,13,
  10. Diana L. Cousminer14,15,16,
  11. Elisabeth Thiering17,18,
  12. Nicholas J. Timpson19,20,
  13. Tom A. Bond1,
  14. Estelle Lowry21,
  15. Christopher D. Brown22,
  16. Xavier Estivill23,24,25,26,
  17. Virpi Lindi15,
  18. Jonathan P. Bradfield28,
  19. Frank Geller29,
  20. Doug Speed30,31,
  21. Lachlan J. M. Coin1,32,
  22. Marie Loh1,21,33,
  23. Sheila J. Barton34,35,
  24. Lawrence J. Beilin36,
  25. Hans Bisgaard37,
  26. Klaus Bønnelykke37,
  27. Rohia Alili38,
  28. Ida J. Hatoum38,39,40,
  29. Katharina Schramm41,42,
  30. Rufus Cartwright1,43,
  31. Marie-Aline Charles44,
  32. Vincenzo Salerno1,
  33. Karine Clément38,44,
  34. Annique A. J. Claringbould45,
  35. BIOS Consortium,
  36. Cornelia M. van Duijn46,
  37. Elena Moltchanova47,
  38. Johan G. Eriksson48,49,50,
  39. Cathy Elks51,
  40. Bjarke Feenstra29,
  41. Claudia Flexeder17,
  42. Stephen Franks43,
  43. Timothy M. Frayling52,
  44. Rachel M. Freathy52,
  45. Paul Elliott1,53,54,
  46. Elisabeth Widén16,
  47. Hakon Hakonarson14,28,55,56,
  48. Andrew T. Hattersley52,
  49. Alina Rodriguez1,57,
  50. Marco Banterle10,
  51. Joachim Heinrich17,
  52. Barbara Heude44,
  53. John W. Holloway58,
  54. Albert Hofman6,46,
  55. Elina Hyppönen59,60,61,
  56. Hazel Inskip34,62,
  57. Lee M. Kaplan39,40,
  58. Asa K. Hedman63,64,
  59. Esa Läärä65,
  60. Holger Prokisch41,42,
  61. Harald Grallert66,67,
  62. Timo A. Lakka15,68,69,
  63. Debbie A. Lawlor19,20,
  64. Mads Melbye29,70,71,
  65. Tarunveer S. Ahluwalia37,
  66. Marcella Marinelli25,26,72,
  67. Iona Y. Millwood73,74,
  68. Lyle J. Palmer75,
  69. Craig E. Pennell8,
  70. John R. Perry51,
  71. Susan M. Ring19,20,76,
  72. Markku J. Savolainen77,
  73. Fernando Rivadeneira46,78,
  74. Marie Standl17,
  75. Jordi Sunyer24,25,26,72,
  76. Carla M. T. Tiesler17,18,
  77. Andre G. Uitterlinden46,78,
  78. William Schierding79,
  79. Justin M. O’Sullivan79,80,
  80. Inga Prokopenko11,13,63,81,
  81. Karl-Heinz Herzig82,83,84,85,
  82. George Davey Smith19,20,
  83. Paul O'Reilly1,86,
  84. Janine F. Felix6,7,46,
  85. Jessica L. Buxton87,
  86. Alexandra I. F. Blakemore88,89,
  87. Ken K. Ong51,
  88. Vincent W. V. Jaddoe6,46,,
  89. Struan F. A. Grant14,28,55,56,,,
  90. Sylvain Sebert1,21,82,,,
  91. Mark I. McCarthy63,81,90,,,§,
  92. Marjo-Riitta Järvelin1,21,82,84,88,91,,,
  93. Early Growth Genetics (EGG) Consortium
  1. 1Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  2. 2School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
  3. 3Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK.
  4. 4NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
  5. 5MRC Unit for Lifelong Health and Ageing at UCL, University College London, London, UK.
  6. 6The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  7. 7Department of Paediatrics, Erasmus MC, Sophia Children’s Hospital, Rotterdam, Netherlands.
  8. 8Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia.
  9. 9The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland, Australia.
  10. 10Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
  11. 11Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK.
  12. 12Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK
  13. 13Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Surrey, UK.
  14. 14Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA.
  15. 15Institute of Biomedicine, Department of Physiology, University of Eastern Finland, Kuopio, Finland.
  16. 16Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
  17. 17Institute of Epidemiology I, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich Neuherberg, Germany.
  18. 18Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children’s Hospital, Ludwig-Maximilians University Munich, Munich, Germany.
  19. 19MRC Integrative Epidemiology Unit at the University of Bristol and NIHR Bristol Biomedical Research Center, Bristol, UK.
  20. 20Population Health Science, Bristol Medical School, University of Bristol, Bristol, UK.
  21. 21Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.
  22. 22Department of Genetics and Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  23. 23Genomics and Disease Group, Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG), Barcelona, Catalonia, Spain.
  24. 24Pompeu Fabra University (UPF), Barcelona, Catalonia, Spain.
  25. 25Hospital del Mar Medical Research Institute (IMIM), Barcelona, Catalonia, Spain.
  26. 26Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  27. 27Sidra Medical and Research Center, Doha, Qatar.
  28. 28Center for Applied Genomics, Abramson Research Center, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA.
  29. 29Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
  30. 30Aarhus Institute of Advanced Studies (AIAS), Aarhus University, Aarhus, Denmark.
  31. 31UCL Genetics Institute, University College London, London, UK.
  32. 32Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
  33. 33Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR) Singapore, Singapore.
  34. 34MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK.
  35. 35NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  36. 36Medical School, Royal Perth Hospital, University of Western Australia, Perth, Western Australia, Australia.
  37. 37COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
  38. 38CRNH Ile de France, Hôpital Pitié-Salpêtrière, Paris, France.
  39. 39Obesity, Metabolism, and Nutrition Institute and Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.
  40. 40Department of Medicine, Harvard Medical School, Boston, MA, USA.
  41. 41Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.
  42. 42Institute of Human Genetics, Technische Universität München, München, Germany.
  43. 43Institute for Reproductive and Developmental Biology, Imperial College London, London, UK.
  44. 44Inserm, UMR 1153 (CRESS), Paris Descartes University, Villejuif, Paris, France.
  45. 45University Medical Centre Groningen, Department of Genetics, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands.
  46. 46Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  47. 47Department of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand.
  48. 48Department of General Practice and Primary Health Care, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland.
  49. 49Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
  50. 50Folkhalsan Research Center, Helsinki, Finland.
  51. 51MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
  52. 52Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.
  53. 53National Institute for Health Research, Imperial College Biomedical Research Centre, London, UK.
  54. 54Health Data Research UK London, Imperial College London, London, UK.
  55. 55Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  56. 56Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  57. 57School of Psychology, College of Social Science, University of Lincoln Brayford Pool Lincoln, Lincolnshire, UK.
  58. 58Human Genetics and Medical Genomics, Faculty of Medicine, University of Southampton, Southampton, UK.
  59. 59South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  60. 60Great Ormond Street Hospital Institute of Child Health, University College London, London, UK.
  61. 61Australian Centre for Precision Health, University of South Australia Cancer Research Institute, North Terrace, Adelaide, South Australia, Australia.
  62. 62NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  63. 63Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  64. 64Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
  65. 65Research Unit of Mathematical Sciences, University of Oulu, Oulu, Finland.
  66. 66Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  67. 67German Center for Diabetes Research (DZD), Neuherberg, Germany.
  68. 68Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
  69. 69Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
  70. 70Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  71. 71Department of Medicine, Stanford University Medical School, Stanford, CA, USA.
  72. 72ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
  73. 73Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of Oxford, Old Road Campus, Oxford, UK.
  74. 74Medical Research Council Population Health Research Unit (MRC PHRU) at the University of Oxford, Oxford, UK.
  75. 75School of Public Health and Robinson Research Institute, University of Adelaide, Adelaide, Australia.
  76. 76Avon Longitudinal Study of Parents and Children, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  77. 77Division of Internal Medicine, and Biocenter of Oulu, Faculty of Medicine, Oulu University, Oulu, Finland.
  78. 78Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
  79. 79Liggins Institute, University of Auckland, Auckland, New Zealand.
  80. 80A Better Start—National Science, Challenge, University of Auckland, Auckland, New Zealand.
  81. 81Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Headington, Oxford, UK.
  82. 82Biocenter Oulu, University of Oulu, Oulu, Finland.
  83. 83Research Unit of Biomedicine, University Oulu, Oulu, Finland.
  84. 84Medical Research Center and Oulu University Hospital, University of Oulu, Oulu, Finland.
  85. 85Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
  86. 86MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, De Crespigny Park, London, UK.
  87. 87School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston upon Thames, UK.
  88. 88Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.
  89. 89Section of Investigative Medicine, Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
  90. 90Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
  91. 91Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
  1. Corresponding author. Email: m.jarvelin{at}imperial.ac.uk (M.-R.J.); mark.mccarthy{at}drl.ox.ac.uk (M.I.M.); grants{at}chop.edu (S.F.A.G.); sylvain.sebert{at}oulu.fi (S.S.)
  • * These authors contributed equally to this work.

  • These authors jointly directed this work.

  • § Present address: Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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