Research ArticleHUMAN GENETICS

Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe

See allHide authors and affiliations

Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaaw3492
DOI: 10.1126/sciadv.aaw3492

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication December 12, 2018
  • Resubmitted April 10, 2019
  • Accepted for publication August 6, 2019
  • .

Author Information

  1. A. Raveane1,2,*,,
  2. S. Aneli2,3,4,*,,
  3. F. Montinaro2,5,*,,
  4. G. Athanasiadis6,
  5. S. Barlera7,
  6. G. Birolo3,4,
  7. G. Boncoraglio8,9,
  8. A. M. Di Blasio10,
  9. C. Di Gaetano3,4,
  10. L. Pagani5,11,
  11. S. Parolo12,,
  12. P. Paschou13,
  13. A. Piazza3,14,
  14. G. Stamatoyannopoulos15,§,
  15. A. Angius16,
  16. N. Brucato17,
  17. F. Cucca16,
  18. G. Hellenthal18,
  19. A. Mulas19,
  20. M. Peyret-Guzzon20,
  21. M. Zoledziewska16,
  22. A. Baali21,
  23. C. Bycroft20,,
  24. M. Cherkaoui21,
  25. J. Chiaroni22,23,
  26. J. Di Cristofaro22,23,
  27. C. Dina24,
  28. J. M. Dugoujon17,
  29. P. Galan25,
  30. J. Giemza24,
  31. T. Kivisild5,26,
  32. S. Mazieres22,
  33. M. Melhaoui27,
  34. M. Metspalu5,
  35. S. Myers20,
  36. L. Pereira28,29,
  37. F. X. Ricaut17,
  38. F. Brisighelli30,
  39. I. Cardinali31,
  40. V. Grugni1,
  41. H. Lancioni31,
  42. V. L. Pascali30,
  43. A. Torroni1,
  44. O. Semino1,
  45. G. Matullo3,4,,
  46. A. Achilli1,,
  47. A. Olivieri1, and
  48. C. Capelli2,*,
  1. 1Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, Pavia, Italy.
  2. 2Department of Zoology, University of Oxford, Oxford, UK.
  3. 3Department of Medical Sciences, University of Turin, Turin, Italy.
  4. 4IIGM (Italian Institute for Genomic Medicine), Turin, Italy.
  5. 5Estonian Biocentre, Institute of Genomics, University of Tartu, Tartu, Estonia.
  6. 6Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
  7. 7Department of Cardiovascular Research, Istituto di Ricovero e Cura a Carattere Scientifico–Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
  8. 8Department of Cerebrovascular Diseases, IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
  9. 9PhD Program in Neuroscience, University Milano-Bicocca, Monza, Italy.
  10. 10Istituto Auxologico Italiano, IRCCS, Centro di Ricerche e Tecnologie Biomediche, Milano, Italy.
  11. 11APE lab, Department of Biology, University of Padua, Padua, Italy.
  12. 12Computational Biology Unit, Institute of Molecular Genetics, National Research Council, Pavia, Italy.
  13. 13Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
  14. 14Academy of Sciences, Turin, Italy.
  15. 15Department of Medicine and Genome Sciences, University of Washington, Seattle, WA, USA.
  16. 16Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
  17. 17Evolutionary Medicine Group, Laboratoire d’Anthropologie Moléculaire et Imagerie de Synthèse, Centre National de la Recherche Scientifique (CNRS), Université de Toulouse, Toulouse, France.
  18. 18University College London Genetics Institute (UGI), University College London, London, UK.
  19. 19Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Lanusei, Italy.
  20. 20The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  21. 21Faculté des Sciences Semlalia de Marrakech (FSSM), Université Cadi Ayyad, Marrakech, Morocco.
  22. 22Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France.
  23. 23Etablissement Français du Sang PACA Corse, Biologie des Groupes Sanguins, Marseille, France.
  24. 24l’institut du thorax, INSERM, CNRS, University of Nantes, Nantes, France.
  25. 25Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Université Paris 13/Inserm U1153/Inra U1125/ Cnam, COMUE Sorbonne Paris Cité, F-93017 Bobigny, France.
  26. 26Department of Human Genetics, KU Leuven, Herestraat 49, box 604, Leuven 3000, Belgium.
  27. 27Faculté des Sciences, Université Mohammed Premier, Oujda, Morocco.
  28. 28i3S–Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  29. 29IPATIMUP–Instituto de Patologia e Imunologia Molecular, Universidade do Porto, Porto, Portugal.
  30. 30Section of Legal Medicine, Institute of Public Health, Catholic University of the Sacred Heart, Rome, Italy.
  31. 31Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy.
  1. *Corresponding author. Email: alessandro.raveane01{at}universitadipavia.it (A.R.); serena.aneli{at}gmail.com (S.A.); francesco.montinaro{at}gmail.com (F.M.); cristian.capelli{at}zoo.ox.ac.uk (C.C.)
  • These authors contributed equally to this work

  • Present address: Fondazione the Microsoft Research, University of Trento Centre for Computational and Systems Biology (COSBI), Piazza Manifattura 1, 38068 Rovereto (TN), Italy.

  • § Deceased.

  • Present address: Genomics Plc, King Charles House, Park End Street, Oxford OX1 1JD, UK.

  • Co-senior authors.

Altmetric

Article usage

Article usage: August 2019 to December 2019

AbstractFullPdf
Aug 2019011
Sep 2019198116271933
Oct 2019202542413
Nov 2019102304304
Dec 2019669770

Stay Connected to Science Advances

Navigate This Article