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Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors

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Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaaw3818
DOI: 10.1126/sciadv.aaw3818

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication December 18, 2018
  • Accepted for publication August 2, 2019
  • .

Author Information

  1. Jan Felix1,
  2. Katharina Weinhäupl1,
  3. Christophe Chipot2,3,4,
  4. François Dehez2,3,
  5. Audrey Hessel1,
  6. Diego F. Gauto1,
  7. Cecile Morlot1,
  8. Olga Abian5,6,7,8,
  9. Irina Gutsche1,
  10. Adrian Velazquez-Campoy5,6,7,9,
  11. Paul Schanda1,* and
  12. Hugo Fraga1,10,11,*
  1. 1Institut de Biologie Structurale, Université Grenoble Alpes, CEA, CNRS, IBS, 71 Avenue des Martyrs, F-38044 Grenoble, France.
  2. 2LPCT, UMR 7019 Université de Lorraine CNRS, Vandoeuvre-les-Nancy F-54500, France.
  3. 3Laboratoire International Associé CNRS and University of Illinois at Urbana−Champaign, Vandoeuvre-les-Nancy F-54506, France.
  4. 4Department of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, IL 61801, USA.
  5. 5Institute of Biocomputation and Physics of Complex Systems (BIFI), Joint Units IQFR-CSIC-BIFI and GBsC-CSIC-BIFI, and Department of Biochemistry and Molecular and Cell Biology, Universidad de Zaragoza, 50018 Zaragoza, Spain.
  6. 6Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain.
  7. 7Biomedical Research Networking Centre for Liver and Digestive Diseases (CIBERehd), Madrid, Spain.
  8. 8Aragon Health Sciences Institute (IACS), 50009 Zaragoza, Spain.
  9. 9Fundacion ARAID, Government of Aragon, 50018 Zaragoza, Spain.
  10. 10Departamento de Biomedicina, Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
  11. 11i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  1. *Corresponding author. Email: hfraga{at}med.up.pt (H.F.); paul.schanda{at}ibs.fr (P.S.)

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