Research ArticleHUMAN GENETICS

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

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Science Advances  11 Sep 2019:
Vol. 5, no. 9, eaaw7781
DOI: 10.1126/sciadv.aaw7781

Article Information

vol. 5 no. 9

Online ISSN: 
  • Received for publication January 24, 2019
  • Accepted for publication August 7, 2019
  • .

Author Information

  1. Darko Bosnakovski1,2,3,
  2. Meiricris T. da Silva1,2,*,
  3. Sithara T. Sunny1,2,
  4. Elizabeth T. Ener1,2,
  5. Erik A. Toso1,2,
  6. Ce Yuan4,
  7. Ziyou Cui1,2,
  8. Michael A. Walters5,
  9. Ajit Jadhav6 and
  10. Michael Kyba1,2,
  1. 1Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
  2. 2Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.
  3. 3Faculty of Medical Sciences, University Goce Delcev—Štip, Štip 2000, Republic of North Macedonia.
  4. 4Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.
  5. 5Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN 55455, USA.
  6. 6National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  1. Corresponding author. Email: kyba{at}
  • * Present address: Laboratory of Skeletal Muscle Plasticity, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.


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Article usage: September 2019 to December 2019

Sep 20191262634530
Oct 201932450164
Nov 20191723378
Dec 20191012143

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