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Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy

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Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaax2066
DOI: 10.1126/sciadv.aax2066

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication March 2, 2019
  • Accepted for publication July 31, 2019
  • .

Author Information

  1. Rebecca C. Ahrens-Nicklas1,*,
  2. Christopher T. Pappas2,*,
  3. Gerrie P. Farman2,
  4. Rachel M. Mayfield2,
  5. Tania M. Larrinaga2,
  6. Livija Medne1,
  7. Alyssa Ritter1,
  8. Ian D. Krantz1,
  9. Chaya Murali1,,
  10. Kimberly Y. Lin3,
  11. Justin H. Berger3,
  12. Sabrina W. Yum4,
  13. Chrystalle Katte Carreon5 and
  14. Carol C. Gregorio2,
  1. 1Division of Human Genetics, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  2. 2Department of Cellular and Molecular Medicine and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ, USA.
  3. 3Division of Pediatric Cardiology, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  4. 4Division of Pediatric Neurology, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  5. 5Department of Pathology, The Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  1. Corresponding author. Email: gregorio{at}email.arizona.edu
  • * These authors contributed equally to this work.

  • Present address: Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza Mail Stop BCM225, Houston, TX 77030, USA.

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