Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Lei Wang; Lixiao Zhang; Li Li; Jingsheng Jiang; Zhen Zheng; Jialin Shang; Chengxiang Wang; Weilin Chen; Qichao Bao; Xiaoli Xu; Zhengyu Jiang; Jian Zhang; Qidong You

doi:10.1126/sciadv.aax2277

Research ArticleCANCER

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

View ORCID ProfileLei Wang ¹,²,
Lixiao Zhang¹,²,
Li Li¹,²,
Jingsheng Jiang¹,²,
Zhen Zheng³,
Jialin Shang³,
Chengxiang Wang³,
Weilin Chen¹,²,
Qichao Bao¹,²,
View ORCID ProfileXiaoli Xu¹,²,
View ORCID ProfileZhengyu Jiang ¹,²,*,
View ORCID ProfileJian Zhang³,⁴,* and
View ORCID ProfileQidong You ¹,²,*

¹State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
²Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
³Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.
⁴School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

↵*Corresponding author. Email: jiangzhengyucpu{at}163.com (Z.J.); jian.zhang{at}sjtu.edu.cn (J.Z.); youqd{at}163.com (Q.Y.)

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Science Advances 18 Sep 2019:
Vol. 5, no. 9, eaax2277
DOI: 10.1126/sciadv.aax2277

Lei Wang

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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ORCID record for Lei Wang

Lixiao Zhang

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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Li Li

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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Jingsheng Jiang

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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Zhen Zheng

3Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Medicinal Bioinformatics Center, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai, 200025, China.

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Jialin Shang

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Chengxiang Wang

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Weilin Chen

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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Qichao Bao

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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Xiaoli Xu

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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Zhengyu Jiang

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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For correspondence: jiangzhengyucpu@163.com jian.zhang@sjtu.edu.cn youqd@163.com

Jian Zhang

4School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.

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For correspondence: jiangzhengyucpu@163.com jian.zhang@sjtu.edu.cn youqd@163.com

Qidong You

1State Key Laboratory of Natural Medicines and Jiang Su Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

2Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

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ORCID record for Qidong You
For correspondence: jiangzhengyucpu@163.com jian.zhang@sjtu.edu.cn youqd@163.com

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