Research ArticleCANCER

ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

See allHide authors and affiliations

Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaax2770
DOI: 10.1126/sciadv.aax2770

Article Information

vol. 5 no. 9

Online ISSN: 
  • Received for publication March 8, 2019
  • Accepted for publication August 5, 2019
  • .

Author Information

  1. Praneeth R. Kuninty1,
  2. Ruchi Bansal1,*,
  3. Susanna W. L. De Geus2,*,
  4. Deby F. Mardhian1,
  5. Jonas Schnittert1,
  6. Joop van Baarlen3,
  7. Gert Storm1,4,
  8. Maarten F. Bijlsma5,
  9. Hanneke W. van Laarhoven5,
  10. Josbert M. Metselaar6,7,
  11. Peter J. K. Kuppen2,
  12. Alexander L. Vahrmeijer2,
  13. Arne Östman8,
  14. Cornelis F. M. Sier2 and
  15. Jai Prakash1,6,8,
  1. 1Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
  2. 2Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
  3. 3Laboratory Pathology Oost Netherlands (LabPON), Hengelo, Netherlands.
  4. 4Department of Pharmaceutics, Utrecht University, Utrecht, Netherlands.
  5. 5Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
  6. 6ScarTec Therapeutics BV, Enschede, Netherlands.
  7. 7Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH University Clinic, Forckenbeckstrasse 55, 52074 Aachen, Germany.
  8. 8Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.
  1. Corresponding author. Email: j.prakash{at}
  • * These authors contributed equally to this work.


Article usage

Article usage: August 2019 to February 2020

Aug 2019011
Sep 20192783631966
Oct 201916666191
Nov 20195539128
Dec 201951100103
Jan 2020395891
Feb 2020031358

Stay Connected to Science Advances

Navigate This Article