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ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

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Science Advances  04 Sep 2019:
Vol. 5, no. 9, eaax2770
DOI: 10.1126/sciadv.aax2770

Article Information

vol. 5 no. 9

Online ISSN: 
  • Received for publication March 8, 2019
  • Accepted for publication August 5, 2019
  • .

Author Information

  1. Praneeth R. Kuninty1,
  2. Ruchi Bansal1,*,
  3. Susanna W. L. De Geus2,*,
  4. Deby F. Mardhian1,
  5. Jonas Schnittert1,
  6. Joop van Baarlen3,
  7. Gert Storm1,4,
  8. Maarten F. Bijlsma5,
  9. Hanneke W. van Laarhoven5,
  10. Josbert M. Metselaar6,7,
  11. Peter J. K. Kuppen2,
  12. Alexander L. Vahrmeijer2,
  13. Arne Östman8,
  14. Cornelis F. M. Sier2 and
  15. Jai Prakash1,6,8,
  1. 1Department of Biomaterials, Science and Technology, Section: Targeted Therapeutics, Faculty of Science and Technology, University of Twente, Enschede, Netherlands.
  2. 2Department of Surgery, Leiden University Medical Center, Leiden, Netherlands.
  3. 3Laboratory Pathology Oost Netherlands (LabPON), Hengelo, Netherlands.
  4. 4Department of Pharmaceutics, Utrecht University, Utrecht, Netherlands.
  5. 5Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands.
  6. 6ScarTec Therapeutics BV, Enschede, Netherlands.
  7. 7Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH University Clinic, Forckenbeckstrasse 55, 52074 Aachen, Germany.
  8. 8Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institutet, Stockholm, Sweden.
  1. Corresponding author. Email: j.prakash{at}
  • * These authors contributed equally to this work.


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