Research ArticleCANCER

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors

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Science Advances  18 Sep 2019:
Vol. 5, no. 9, eaax6352
DOI: 10.1126/sciadv.aax6352

Article Information

vol. 5 no. 9

Online ISSN: 
History: 
  • Received for publication April 9, 2019
  • Accepted for publication August 21, 2019
  • .

Author Information

  1. Akihiro Yoshida1,*,,
  2. Yiwen Bu1,
  3. Shuo Qie1,
  4. John Wrangle2,
  5. E. Ramsay Camp3,
  6. E. Starr Hazard4,
  7. Gary Hardiman2,4,,
  8. Renée de Leeuw5,§,
  9. Karen E. Knudsen5 and
  10. J. Alan Diehl1,*,
  1. 1Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
  2. 2Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
  3. 3Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA.
  4. 4Center for Genomic Medicine Bioinformatics, Medical University of South Carolina, Charleston, SC 29425, USA.
  5. 5Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.
  1. *Corresponding author. Email: jad283{at}case.edu (J.A.D.); axy234{at}case.edu (A.Y.)
  • Present address: Department of Biochemistry, Case Western Reserve University, 10900 Euclid Avenue Cleveland, OH 44106, USA.

  • Present address: Institute for Global Food Security, Biological Sciences, 19 Chlorine Gardens, Belfast BT9 5DL, Ireland.

  • § Present address: Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA.

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