Research ArticleIMMUNOLOGY

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse

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Science Advances  01 Jan 2020:
Vol. 6, no. 1, eaay2432
DOI: 10.1126/sciadv.aay2432

Article Information

vol. 6 no. 1

Online ISSN: 
  • Received for publication June 3, 2019
  • Accepted for publication October 31, 2019
  • .

Author Information

  1. D. Thumkeo1,2,*,,
  2. Y. Katsura1,3,*,
  3. Y. Nishimura4,
  4. P. Kanchanawong4,5,
  5. K. Tohyama1,3,
  6. T. Ishizaki6,
  7. S. Kitajima7,,
  8. C. Takahashi7,
  9. T. Hirata8,
  10. N. Watanabe3,9,
  11. M. F. Krummel2 and
  12. S. Narumiya1,
  1. 1Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  2. 2Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
  3. 3Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan.
  4. 4Mechanobiology Institute, National University of Singapore, Singapore, Republic of Singapore.
  5. 5Department of Biomedical Engineering, National University of Singapore, Singapore, Republic of Singapore.
  6. 6Department of Pharmacology, Oita University Graduate School of Medicine, Oita, Japan.
  7. 7Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan.
  8. 8Department of Fundamental Biosciences, Shiga University of Medical Science, Shiga, Japan.
  9. 9Laboratory of Single-Molecule Cell Biology, Kyoto University Graduate School of Biostudies, Kyoto, Japan.
  1. Corresponding author. Email: d.thumkeo{at} (D.T.); snaru{at} (S.N.)
  • * These authors contributed equally to this work.

  • Present address: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.


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