Contents
March 2020
Vol 6, Issue 10
Vol 6, Issue 10
Contents
Research Articles
- Prevalence of critically endangered European eel (Anguilla anguilla) in Hong Kong supermarkets
DNA barcoding reveals the unexpected prevalence of illegally traded European eel in Hong Kong supermarkets.
- Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
CRISPR homing drive variants have different numbers of multiplexed gRNAs for optimal performance.
- MTH1 inhibitor amplifies the lethality of reactive oxygen species to tumor in photodynamic therapy
An MTH1 inhibitor is integrated with nanoparticles to enhance therapy effect of reactive oxygen species in cancer treatment.
- In silico experiments of bone remodeling explore metabolic diseases and their drug treatment
In silico experiments of bone remodeling enable observation and prediction of physiological and pathological bone conditions.
- Exchange bias and quantum anomalous Hall effect in the MnBi2Te4/CrI3 heterostructure
We propose the zero-field quantum anomalous Hall effect in a 2D van der Waals magnetic heterostructure.
- Lateral propagation–induced subduction initiation at passive continental margins controlled by preexisting lithospheric weakness
Subduction initiation at weakened passive continental margin could be induced by lateral propagation of existing subduction zones.
- Biochemical and structural cues of 3D-printed matrix synergistically direct MSC differentiation for functional sweat gland regeneration
3D-bioprinted microenvironment directs MSC differentiation and promotes SG regeneration.
- Mouthpart homologies and life habits of Mesozoic long-proboscid scorpionflies
Long-proboscid scorpionflies from amber reveal the variety and complexity of mid-Cretaceous pollinating insects.
- Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics
A protein interface between paramyxovirus polymerase and nucleocapsid is involved in regulating viral replication dynamics.
- Ultrahigh areal number density solid-state on-chip microsupercapacitors via electrohydrodynamic jet printing
Solid-state microsupercapacitors with ultrahigh areal-number-density are integrated on a chip via high-fidelity printing.
- A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies
We provide an empirical model to evaluate and rank data obtained from preclinical tuberculosis vaccine studies.
- Nanoscale integrin cluster dynamics controls cellular mechanosensing via FAKY397 phosphorylation
Mechanotransduction model provides insights into integrin clustering/disassembly dynamics and associated FAK phosphorylation.
- Emergent collective colloidal currents generated via exchange dynamics in a broken dimer state
Colloidal currents can be generated via a novel exchange mechanism based on combination of confinement and dipolar interactions.
- Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors
We uncovered structural and functional changes induced by mutations that dictate the DNA editing activity of ABE enzymes.
- The spin Hall effect of Bi-Sb alloys driven by thermally excited Dirac-like electrons
Dirac-like electrons in Bi-Sb alloys are extremely effective in generating spin current and have large spin current mobility.
- An ultrastable lithium metal anode enabled by designed metal fluoride spansules
An innovative strategy enabled by spansules is rationally designed for the lithium metal anode to realize an ultralong cycle life.
- Mechanically controllable nonlinear dielectrics
Control of nonlinear dielectrics can be realized by mechanical bending.
- Tethered peptide neurotoxins display two blocking mechanisms in the K+ channel pore as do their untethered analogs
Hijacking the cell machinery to tether neurotoxins near their surface receptors (zombie scans) reveals sites of interaction.
- One-component order parameter in URu2Si2 uncovered by resonant ultrasound spectroscopy and machine learning
Resonant ultrasound spectroscopy and machine learning are used to rule out many theories of hidden order in URu2Si2.
- Human transport of thirdhand tobacco smoke: A prominent source of hazardous air pollutants into indoor nonsmoking environments
Tobacco smoke off-gassing from prior exposure releases contaminants that are equivalent to several cigarettes of secondhand smoke.
- Direct observation of topological edge states in silicon photonic crystals: Spin, dispersion, and chiral routing
We directly observe the spin, dispersion, and guiding of topological states in photonic crystals.
- Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses
A cocktail therapeutic formulation is developed for localized chemoimmunotherapy to trigger systemic antitumor responses.
- Co-occurrence of Acheulian and Oldowan artifacts with Homo erectus cranial fossils from Gona, Afar, Ethiopia
Homo erectus was anatomically variable and behaviorally flexible using both Oldowan and Acheulian artifacts.
- Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells
Epigenetic regulation by the chromatin modifier Polycomb is modulated across cell cycle in stem cells.
- Novel technology for storage and distribution of live vaccines and other biological medicines at ambient temperature
Temperature-stable dissolving film eliminates cold-chain storage and successfully immunizes mice sublingually and buccally.
- One-dimensional hexagonal boron nitride conducting channel
The 6′6′ twin boundary of two-dimensional hexagonal boron nitride is an ultimate one-dimensional conducting channel.
- Antithetic population response to antibiotics in a polybacterial community
The collective response of mixed bacterial ecosystems to antibiotics can be opposite to that of single-species cultures.
- Aspiration-assisted bioprinting for precise positioning of biologics
Aspiration-assisted bioprinting enables precise positioning of viscoelastic spheroids in both scaffold-based and free manner.
- Efficient inverse graphics in biological face processing
Neural networks in the primate brain may invert a graphics style model of how 3D object shapes and textures cause observed images.
- Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes
IL-1 axis activation during placental malaria induces poor pregnancy outcomes that are obliterated after treatment with Anakinra.
- A molecular rack and pinion actuates a cell-surface adhesin and enables bacterial gliding motility
This manuscript proposes that gliding bacteria use a molecular rack and pinion machinery for motion.
- Systems-level investigation of aqueous batteries for understanding the benefit of water-in-salt electrolyte by synchrotron nanoimaging
Synchrotron microscopy visualizes and furthers the understanding of cycling stability of water-in-salt Li-ion batteries.
- Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning
Sequence constraints associated with topological energetics restrict the evolution and mutational tolerance of membrane proteins.
- High-resolution tomographic analysis of in vitro 3D glioblastoma tumor model under long-term drug treatment
Mesoscopic fluorescence molecular tomography enables longitudinal study of 3D glioblastoma model in response to drug treatment.
- Mapping the structure and biological functions within mesenchymal bodies using microfluidics
MSC spheroids self-organize in a hierarchical manner, resulting in a spatial patterning of the function of individual cells.
- Lasting organ-level bone mechanoadaptation is unrelated to local strain
Bones’ four-dimensional response to momentary loading is lasting and coordinated at the organ level.
- Cooperative particle rearrangements facilitate the self-organized growth of colloidal crystal arrays on strain-relief patterns
Strain-relief pattern formation in colloidal heteroepitaxy enables the fabrication of hierarchically ordered surface structures.
- Giant extraordinary transmission of acoustic waves through a nanowire
Wave concentration beyond the diffraction limit by extraordinary acoustic transmission of bulk waves through a nanowire meta-atom.
- An algal enzyme required for biosynthesis of the most abundant marine carotenoids
A key enzyme in light-harvesting pigment formation in many algae stems from duplication of a gene involved in photoprotection.
- Initialization of quantum simulators by sympathetic cooling
We demonstrate the preparation of ground states of largely arbitrary Hamiltonians by sympathetic cooling with a single particle.
- Femtosecond visualization of oxygen vacancies in metal oxides
Femtosecond spectroscopy combined with first-principle calculations enables determination of oxygen-vacancy configuration.
About The Cover
ONLINE COVER Integrins—proteins on cell membranes that function as receptors—play a key role in cell function, attaching the cytoskeleton to a three-dimensional network of large molecules outside the cell that help bind it to its neighbors. The role of integrin in these cellular processes is highly complex, and the organization of proteins within sites where the cell adheres to large extracellular molecules is not well understood, leading scientists to seek modelling approaches to identify its regulatory mechanisms. To explain how the molecular organization of proteins at adhesion sites regulated by integrin control shape, stability, signaling, and the transmission of forces, Cheng et al. developed a modeling approach based on a hexagonal grid-like pattern where integrin proteins are free to change positions or form clusters. The modeling results predicted that the ways in which integrins cluster ultimately determine how different cell types convert mechanical signals—suggesting a new pathway through which cells to respond to their mechanical environment. [CREDIT: MIN LIN, XI'AN JIAOTONG UNIVERSITY]
