Research ArticleIMMUNOLOGY

In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation

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Science Advances  13 Mar 2020:
Vol. 6, no. 11, eaax8429
DOI: 10.1126/sciadv.aax8429

Article Information

vol. 6 no. 11

Online ISSN: 
History: 
  • Received for publication April 27, 2019
  • Accepted for publication December 17, 2019
  • .

Author Information

  1. James D. Fisher1,2,
  2. Wensheng Zhang3,
  3. Stephen C. Balmert1,4,
  4. Ali M. Aral1,5,
  5. Abhinav P. Acharya6,
  6. Yalcin Kulahci6,
  7. Jingjing Li3,
  8. Heth R. Turnquist5,7,8,9,
  9. Angus W. Thomson5,7,8,
  10. Mario G. Solari3,9,
  11. Vijay S. Gorantla10,* and
  12. Steven R. Little1,6,8,9,11,12,*
  1. 1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
  2. 2Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA.
  3. 3Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  4. 4Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
  5. 5Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  6. 6Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
  7. 7Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.
  8. 8Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
  9. 9McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  10. 10Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  11. 11Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
  12. 12Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
  1. *Corresponding author. Email: srlittle{at}pitt.edu (S.R.L.); vgorantl{at}wakehealth.edu (V.S.G.)

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