Research ArticleBIOCHEMISTRY

Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples

See allHide authors and affiliations

Science Advances  11 Mar 2020:
Vol. 6, no. 11, eaay0888
DOI: 10.1126/sciadv.aay0888

Article Information

vol. 6 no. 11

Online ISSN: 
History: 
  • Received for publication May 20, 2019
  • Accepted for publication December 11, 2019
  • .

Author Information

  1. Shingo Sakamoto1,
  2. Toru Komatsu1,*,
  3. Rikiya Watanabe2,*,
  4. Yi Zhang3,
  5. Taiki Inoue1,
  6. Mitsuyasu Kawaguchi4,
  7. Hidehiko Nakagawa4,
  8. Takaaki Ueno5,
  9. Takuji Okusaka6,
  10. Kazufumi Honda7,
  11. Hiroyuki Noji8,* and
  12. Yasuteru Urano1,9,10,*
  1. 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  2. 2Molecular Physiology Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
  3. 3Super-cutting-edge Grand and Advanced Research (SUGAR) Program, Institute for Extra-cutting-edge Science and Technology Avant-garde Research (X-star), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), 2-15 Natsushima-cho, Yokosuka 237-0061, Japan.
  4. 4Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabedori, Mizuho-ku, Nagoya-shi, Aichi 467-8603, Japan.
  5. 5Department of Oral and Maxillofacial Surgery, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-shi, Osaka 569-8686, Japan.
  6. 6Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
  7. 7Department of Biomarkers for Early Detection of Cancer, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
  8. 8Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  9. 9Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
  10. 10Core Research for Evolutional Science and Technology (CREST) Investigator, Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan.
  1. *Corresponding author. Email: tkomatsu{at}mol.f.u-tokyo.ac.jp (T.K.); rikiya.watanabe{at}riken.jp (R.W.); hnoji{at}appchem.t.u-tokyo.ac.jp (H.N.); uranokun{at}m.u-tokyo.ac.jp (Y.U.)

Altmetric

Article usage

Article usage: March 2020 to June 2021

AbstractFullPdf
Mar 20202913755990
Apr 202056653331
May 202022573193
Jun 202021424122
Jul 202043340125
Aug 202019440111
Sep 202027321128
Oct 202018369130
Nov 20202928594
Dec 2020722377
Jan 202124264111
Feb 20211127170
Mar 202121300111
Apr 202124397125
May 202128259109
Jun 2021611621

Stay Connected to Science Advances

Navigate This Article