Research ArticleHEALTH AND MEDICINE

Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming

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Science Advances  11 Mar 2020:
Vol. 6, no. 11, eaay1109
DOI: 10.1126/sciadv.aay1109

Article Information

vol. 6 no. 11

Online ISSN: 
History: 
  • Received for publication May 21, 2019
  • Accepted for publication December 13, 2019
  • .

Author Information

  1. Meike Kespohl1,2,
  2. Clara Bredow1,
  3. Karin Klingel3,
  4. Martin Voß1,
  5. Anna Paeschke1,
  6. Martin Zickler1,*,
  7. Wolfgang Poller4,
  8. Ziya Kaya5,6,
  9. Johannes Eckstein1,
  10. Henry Fechner7,
  11. Joachim Spranger8,
  12. Michael Fähling9,
  13. Eva Katrin Wirth8,
  14. Lilliana Radoshevich10,
  15. Fabien Thery11,12,
  16. Francis Impens11,12,13,
  17. Nikolaus Berndt1,14,
  18. Klaus-Peter Knobeloch15 and
  19. Antje Beling1,2,
  1. 1Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Berlin, Germany.
  2. 2Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Berlin, Germany.
  3. 3University of Tuebingen, Cardiopathology, Institute for Pathology and Neuropathology, Tuebingen, Germany.
  4. 4Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Clinic for Cardiology, Campus Benjamin Franklin, Berlin, Germany.
  5. 5Universitätsklinikum Heidelberg, Medizinische Klinik für Innere Medizin III: Kardiologie, Angiologie und Pneumologie, Heidelberg, Germany.
  6. 6Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Heidelberg, Germany.
  7. 7Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany.
  8. 8Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany.
  9. 9Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Vegetative Physiology, Berlin, Germany.
  10. 10Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
  11. 11Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
  12. 12VIB Center for Medical Biotechnology, Ghent, Belgium.
  13. 13VIB Proteomics Core, Ghent, Belgium.
  14. 14Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Berlin, Germany.
  15. 15University of Freiburg, Institute of Neuropathology, Freiburg, Germany.
  1. Corresponding author. Email: antje.beling{at}charite.de
  • * Present address: Research Group Viral Zoonosis and Adaptation, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.

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