Contents
March 2020
Vol 6, Issue 12
Vol 6, Issue 12
Contents
Research Articles
- A wearable freestanding electrochemical sensing system
We devised a strategy for high-fidelity, wearable biomarker data acquisition and sensor integration with consumer electronics.
- Single-asperity sliding friction across the superconducting phase transition
Nanoscale friction experiments on high-Tc superconductors link energy dissipation during sliding to the electron system.
- Regulation of body length and bone mass by Gpr126/Adgrg6
Adhesion GPCR Gpr126/Adgrg6 regulates mouse body length and bone mass by controlling osteoblast differentiation.
- Tracking Ca2+ ATPase intermediates in real time by x-ray solution scattering
We characterize thus-far elusive domain rearrangements of a calcium-transporting ATPase in the native membrane.
- Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala
Alcohol dependence induces hypersensitivity of the SP/NK-1R system and its regulation of CeA inhibitory transmission.
- Reversible spin storage in metal oxide—fullerene heterojunctions
Hybrid interfaces form a spin capacitor for the generation and storage of spin angular momentum via optical or electronic stimuli.
- Mediterranean radiocarbon offsets and calendar dates for prehistory
Intra-annual offsets in Northern Hemisphere atmospheric radiocarbon levels challenge and complicate Old World radiocarbon dating.
- Two different epigenetic information channels in wild three-spined sticklebacks are involved in salinity adaptation
Detection of both inducible and stable DNA methylation indicates two different epigenetic modes of salinity adaptation.
- 10,000 social brains: Sex differentiation in human brain anatomy
Population variability in social lifestyle is reflected in brain morphology in sex-dependent ways.
- Universal interferometric signatures of a black hole’s photon ring
A black hole image contains a series of increasingly narrow rings measurable with progressively longer interferometers.
- Verification of extreme event attribution: Using out-of-sample observations to assess changes in probabilities of unprecedented events
Using out-of-sample observations to verify extreme event attribution results.
- Massively parallel microwire arrays integrated with CMOS chips for neural recording
Integrating camera chips into neural recording arrays provides a massively parallel brain-machine interface.
- Microscopic pathways for stress relaxation in repulsive colloidal glasses
How residual stresses in colloids generate directional and heterogeneous motions down to fundamental length scales.
- Protecting quantum entanglement from leakage and qubit errors via repetitive parity measurements
We protect two-transmon entanglement from qubit leakage using the same parity checks used to correct standard qubit errors.
- YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma
MOB1 deficiency promotes rapid onset and progression of oral SCC (OSCC) via YAP1 activation.
- No evidence for DNA N6-methyladenine in mammals
Technical errors have resulted in the false discovery of the DNA modification N6-methyladenine in mammals.
- TRPC1 participates in the HSV-1 infection process by facilitating viral entry
TRPC1 channel facilitates virus infection.
- Species-specific molecular responses of wild coral reef fishes during a marine heatwave
Molecular responses of fishes to a heatwave are species specific and do not concur with measures of oxygen uptake in captivity.
- Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing
Macrophages, renowned for clearance of debris and bacteria in the wound, can also uptake signaling inhibitors to promote fibrosis.
- Lipidomics and RNA sequencing reveal a novel subpopulation of nanovesicle within extracellular matrix biomaterials
Matrix-bound nanovesicles (MBVs) are a novel subclass of extracellular vesicles.
- Surface-state Coulomb repulsion accelerates a metal-insulator transition in topological semimetal nanofilms
Increased Coulomb repulsion from surface states substantially modulates quantum confinement in topological semimetal nanofilms.
- A psychological stressor conveyed by appetite-linked neurons
New studies show that POMC neurons linked to appetite suppression also play a key role in stress hormone responses.
- Strong adhesion of wet conducting polymers on diverse substrates
A simple yet general method is reported to realize strong adhesion of various wet conducting polymers on diverse substrates.
- Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach
Photolithographic patterning of DNA leads to the assembly of complex signaling environments to study single-cell behavior.
- Nitrogen addition increased CO2 uptake more than non-CO2 greenhouse gases emissions in a Moso bamboo forest
Moso bamboo forests have greater net carbon uptake benefits with increasing nitrogen deposition in the coming decades.
- A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer
A rationally designed bi-adjuvant nanovaccine enhances neoantigen immunogenicity and enables combination immunotherapy.
- Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury
Activated platelets cause microvascular inflammation via direct activation of perivascular mast cells.
- Development of a CRISPR-SaCas9 system for projection- and function-specific gene editing in the rat brain
A CRISPR-based technique achieves projection- and function-specific gene editing in the rat brain.
- 3D printing of Haversian bone–mimicking scaffolds for multicellular delivery in bone regeneration
Tissue engineering scaffolds are supposed to mimick the native tissue to achieve the functionalized tissue regeneration.
- Ultrasensitive and rapid quantification of rare tumorigenic stem cells in hPSC-derived cardiomyocyte populations
Rare tumorigenic stem cells identified in hPSC-derived cardiomyocytes using stem cell quantitative cytometry.
- Distinguishing cell phenotype using cell epigenotype
Gene expression and chromatin conformation reliably distinguish cell types, enabling equation-free control of human cells.
- Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Redox regulation of STAT3 is targeted by direct inhibition of TrxR1, illuminating a promising link for therapeutic development.
- Liquid dispersions of zeolite monolayers with high catalytic activity prepared by soft-chemical exfoliation
The first direct exfoliation of zeolites in high yield expands potential for catalysts, membranes, and tailored composites.
- National monuments and economic growth in the American West
Protecting public lands as national monuments in the western United States is more help than hindrance to local economies.
- Reconfigurable structure and tunable transport in synchronized active spinner materials
Synchronized active spinners spontaneously form dynamic lattices with reconfigurable order and tunable transport characteristics.
- Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR
NMR studies of A2AAR in lipid bilayers of nanodiscs revealed the mechanism underlying activation of A2AAR by DHA chains.
- Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage
A developmentally regulated mechanism, mediated by a zinc finger protein Zscan4, protects genome integrity in early embryos.
- Past warming trend constrains future warming in CMIP6 models
Strong future warming in some new climate models is less likely as their recent warming is inconsistent with observed trends.
- Surface-anchored framework for generating RhD-epitope stealth red blood cells
A new method generates universal red blood cells for transfusion and requires no blood type match.
- Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke
Nanotherapeutics reverses reperfusion-induced injury in ischemic stroke.
Review
- Nanobiohybrids: Materials approaches for bioaugmentation
We review recent advances and prospects of interfacing functional nanomaterials with biological systems for nanobiohybrids.
About The Cover
ONLINE COVER National monuments in the U.S. West increase the average number of establishments and jobs near the monument and increase the average establishment growth rate, according to a new study. At the same time, monument designation has no effect on the number of jobs that existed before the monument, and has no effect on mining, forestry and other traditional industries that use public lands. The findings suggest that fears of local economic restriction after a national monument designation are unwarranted. It's an issue that came to light most recently in 2017, when U.S. President Donald Trump decreased the size of two Utah national monuments by more than 2 million acres. National monuments in the U.S. are protected lands that contain prehistoric, historic, scientific or cultural structures or objects of interest, and usually contain little developed infrastructure after monument designation. Walls et al. reviewed data on all business establishments within 25 kilometers (about 15.5 miles) in eight states in the U.S. Mountain West before and after designation of 14 monuments between 1900 and 2015. They then compared these data with nearby "control" communities outside the 25-kilometer zone. Monument designation appears to help more than hurt local economies, the researchers conclude. At the same time, these protected public lands provide a variety of other societal benefits from wildlife habitat to carbon sequestration. [CREDIT: TIM FITZHARRIS/MINDEN PICTURES]
