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Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

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Science Advances  20 Mar 2020:
Vol. 6, no. 12, eaax7945
DOI: 10.1126/sciadv.aax7945

Article Information

vol. 6 no. 12

Online ISSN: 
  • Received for publication April 23, 2019
  • Accepted for publication December 23, 2019
  • .

Author Information

  1. S. Busker1,
  2. W. Qian2,
  3. M. Haraldsson3,
  4. B. Espinosa1,
  5. L. Johansson3,
  6. S. Attarha4,
  7. I. Kolosenko5,*,,
  8. J. Liu6,
  9. M. Dagnell1,
  10. D. Grandér5,,
  11. E. S. J. Arnér1,
  12. K. Pokrovskaja Tamm5 and
  13. B. D. G. Page4,7,§
  1. 1Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  2. 2Laboratories for Chemical Biology Umeå, Chemical Biology Consortium Sweden, Umeå University, Umeå, Sweden.
  3. 3Chemical Biology Consortium Sweden, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
  4. 4Department of Oncology and Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
  5. 5Department of Oncology and Pathology, Bioclinicum, Karolinska Institutet, Stockholm, Sweden.
  6. 6Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  7. 7Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.
  1. §Corresponding author. Email:{at}
  • * Present address: Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Novum, Huddinge, Sweden.

  • Present address: Department of Neurology, Yale School of Medicine, New Haven, CT, USA.

  • Deceased.


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