Massively parallel microwire arrays integrated with CMOS chips for neural recording

Abdulmalik Obaid; Mina-Elraheb Hanna; Yu-Wei Wu; Mihaly Kollo; Romeo Racz; Matthew R. Angle; Jan Müller; Nora Brackbill; William Wray; Felix Franke; E. J. Chichilnisky; Andreas Hierlemann; Jun B. Ding; Andreas T. Schaefer; Nicholas A. Melosh

doi:10.1126/sciadv.aay2789

Research ArticleMATERIALS SCIENCE

Massively parallel microwire arrays integrated with CMOS chips for neural recording

View ORCID ProfileAbdulmalik Obaid¹,*,
Mina-Elraheb Hanna¹,²,*,
View ORCID ProfileYu-Wei Wu³,*,
View ORCID ProfileMihaly Kollo⁴,⁵,*,
View ORCID ProfileRomeo Racz⁴,
View ORCID ProfileMatthew R. Angle²,
Jan Müller⁶,
View ORCID ProfileNora Brackbill⁷,
View ORCID ProfileWilliam Wray⁴,
View ORCID ProfileFelix Franke⁶,
View ORCID ProfileE. J. Chichilnisky⁸,
Andreas Hierlemann⁶,
View ORCID ProfileJun B. Ding³,
View ORCID ProfileAndreas T. Schaefer⁴,⁵,†,‡ and
View ORCID ProfileNicholas A. Melosh ¹,†,‡

¹Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
²Paradromics Inc., Austin, TX, USA.
³Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.
⁴Neurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.
⁵Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
⁶Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.
⁷Department of Physics, Stanford University, Stanford, CA, USA.
⁸Departments of Neurosurgery and Ophthalmology, Stanford University, Stanford, CA, USA.

↵‡Corresponding author. Email: nmelosh{at}stanford.edu (N.A.M.); andreas.schaefer{at}crick.ac.uk (A.T.S.)

↵* These authors contributed equally to this work.
↵† These authors share senior authorship.

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Science Advances 20 Mar 2020:
Vol. 6, no. 12, eaay2789
DOI: 10.1126/sciadv.aay2789

Abdulmalik Obaid

1Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.

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Mina-Elraheb Hanna

1Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.

2Paradromics Inc., Austin, TX, USA.

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Yu-Wei Wu

3Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.

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Mihaly Kollo

4Neurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.

5Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

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Romeo Racz

4Neurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.

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Matthew R. Angle

2Paradromics Inc., Austin, TX, USA.

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Jan Müller

6Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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Nora Brackbill

7Department of Physics, Stanford University, Stanford, CA, USA.

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William Wray

4Neurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.

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Felix Franke

6Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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E. J. Chichilnisky

8Departments of Neurosurgery and Ophthalmology, Stanford University, Stanford, CA, USA.

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Andreas Hierlemann

6Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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Jun B. Ding

3Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA.

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Andreas T. Schaefer

4Neurophysiology of Behaviour Laboratory, Francis Crick Institute, London, UK.

5Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

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For correspondence: nmelosh@stanford.edu andreas.schaefer@crick.ac.uk

Nicholas A. Melosh

1Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.

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For correspondence: nmelosh@stanford.edu andreas.schaefer@crick.ac.uk

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