Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

Rajini Srinivasan; Nataliya Nady; Neha Arora; Laura J. Hsieh; Tomek Swigut; Geeta J. Narlikar; Mark Wossidlo; Joanna Wysocka

doi:10.1126/sciadv.aaz9115

Research ArticleGENETICS

Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

View ORCID ProfileRajini Srinivasan¹,*,
View ORCID ProfileNataliya Nady ¹,*,
View ORCID ProfileNeha Arora¹,*,
View ORCID ProfileLaura J. Hsieh²,
View ORCID ProfileTomek Swigut¹,
View ORCID ProfileGeeta J. Narlikar²,
View ORCID ProfileMark Wossidlo¹,³,† and
View ORCID ProfileJoanna Wysocka ¹,⁴,⁵,⁶,†

¹Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
²Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
³Department of Cell and Developmental Biology, Medical University of Vienna, 1090 Vienna, Austria.
⁴Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁵Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
⁶Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

↵†Corresponding author. Email: wysocka{at}stanford.edu (J.W.); mark.wossidlo{at}meduniwien.ac.at (M.W.)

↵* These authors contributed equally to this work.

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Science Advances 20 Mar 2020:
Vol. 6, no. 12, eaaz9115
DOI: 10.1126/sciadv.aaz9115

Rajini Srinivasan

1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Nataliya Nady

1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Neha Arora

1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Laura J. Hsieh

2Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

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Tomek Swigut

1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

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Geeta J. Narlikar

2Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

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Mark Wossidlo

1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

3Department of Cell and Developmental Biology, Medical University of Vienna, 1090 Vienna, Austria.

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For correspondence: wysocka@stanford.edu mark.wossidlo@meduniwien.ac.at

Joanna Wysocka

1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

4Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

5Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

6Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

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For correspondence: wysocka@stanford.edu mark.wossidlo@meduniwien.ac.at

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Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

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