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Research ArticleCANCER
Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming
- View ORCID ProfileChao Wan1,*,
- View ORCID ProfileYajie Sun1,*,
- View ORCID ProfileYu Tian1,*,
- View ORCID ProfileLisen Lu1,
- Xiaomeng Dai1,
- View ORCID ProfileJingshu Meng1,
- Jing Huang1,
- View ORCID ProfileQianyuan He1,
- Bian Wu1,
- Zhanjie Zhang1,
- Ke Jiang2,
- Desheng Hu3,
- Gang Wu1,
- View ORCID ProfileJonathan F. Lovell4,
- View ORCID ProfileHonglin Jin1,† and
- View ORCID ProfileKunyu Yang1,†
- 1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
- 2Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- 3Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- 4Department of Chemical and Biological Engineering, University at Buffalo, State University of New York. Buffalo, NY 14260, USA.
- ↵†Corresponding author. Email: yangky71{at}aliyun.com (K.Y.); jin{at}hust.edu.cn (H.J.)
↵* These authors contributed equally to this work.
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Science Advances 25 Mar 2020:
Vol. 6, no. 13, eaay9789
DOI: 10.1126/sciadv.aay9789
Vol. 6, no. 13, eaay9789
DOI: 10.1126/sciadv.aay9789
Chao Wan
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yajie Sun
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yu Tian
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Lisen Lu
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Xiaomeng Dai
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jingshu Meng
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jing Huang
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Qianyuan He
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Bian Wu
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhanjie Zhang
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Ke Jiang
2Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Desheng Hu
3Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gang Wu
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Jonathan F. Lovell
4Department of Chemical and Biological Engineering, University at Buffalo, State University of New York. Buffalo, NY 14260, USA.
Honglin Jin
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Kunyu Yang
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
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