Research ArticleCELL BIOLOGY

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

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Science Advances  01 Apr 2020:
Vol. 6, no. 14, eaay9572
DOI: 10.1126/sciadv.aay9572

Article Information

vol. 6 no. 14

Online ISSN: 
History: 
  • Received for publication August 1, 2019
  • Accepted for publication January 13, 2020
  • .

Author Information

  1. Stephen D. Carter1,*,
  2. Cheri M. Hampton2,*,,
  3. Robert Langlois2,*,,
  4. Roberto Melero3,
  5. Zachary J. Farino4,§,
  6. Michael J. Calderon5,
  7. Wen Li2,
  8. Callen T. Wallace5,
  9. Ngoc Han Tran6,
  10. Robert A. Grassucci2,
  11. Stephanie E. Siegmund7,8,
  12. Joshua Pemberton9,
  13. Travis J. Morgenstern10,11,
  14. Leanna Eisenman12,
  15. Jenny I. Aguilar10,11,
  16. Nili L. Greenberg10,11,||,
  17. Elana S. Levy10,11,
  18. Edward Yi10,11,
  19. William G. Mitchell10,11,
  20. William J. Rice13,,
  21. Christoph Wigge13,#,
  22. Jyotsna Pilli14,
  23. Emily W. George4,
  24. Despoina Aslanoglou4,
  25. Maïté Courel15,
  26. Robin J. Freyberg4,
  27. Jonathan A. Javitch10,11,
  28. Zachary P. Wills12,
  29. Estela Area-Gomez8,
  30. Sruti Shiva14,16,17,
  31. Francesca Bartolini18,
  32. Allen Volchuk19,
  33. Sandra A. Murray5,
  34. Meir Aridor5,
  35. Kenneth N. Fish4,
  36. Peter Walter6,
  37. Tamas Balla9,
  38. Deborah Fass20,
  39. Sharon G. Wolf21,
  40. Simon C. Watkins5,
  41. José María Carazo3,
  42. Grant J. Jensen22,**,
  43. Joachim Frank2,23,** and
  44. Zachary Freyberg4,5,**
  1. 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  2. 2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
  3. 3Biocomputing Unit, Centro Nacional de Biotecnología–CSIC, Darwin 3, Campus Universidad Autónoma, 28049 Madrid, Spain.
  4. 4Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  5. 5Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  6. 6HHMI, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.
  7. 7Department of Cellular, Molecular and Biophysical Studies, Columbia University Medical Center, New York, NY 10032, USA.
  8. 8Department of Neurology, Columbia University, New York, NY 10032, USA.
  9. 9Section on Molecular Signal Transduction, Program for Developmental Neuroscience, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
  10. 10Department of Psychiatry, Columbia University, New York, NY 10032, USA.
  11. 11Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA.
  12. 12Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  13. 13New York Structural Biology Center, New York, NY 10027, USA.
  14. 14Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  15. 15CNRS-UMR7622, Institut de Biologie Paris-Seine, Université Pierre & Marie Curie, 75252 Paris, France.
  16. 16Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  17. 17Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  18. 18Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
  19. 19Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  20. 20Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
  21. 21Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.
  22. 22HHMI, Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  23. 23Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
  1. **Corresponding author. Email: freyberg{at}pitt.edu (Z.F.); jf2192{at}cumc.columbia.edu (J.F.); jensen{at}caltech.edu (G.J.J.)
  • * These authors contributed equally to this work.

  • Present address: UES Inc. at AFRL/RXAS, Wright-Patterson AFB, Dayton, OH 45433, USA.

  • Present address: Illumina Inc., San Diego, CA 92122, USA.

  • § Present address: Kallyope Inc., New York, NY 10016, USA.

  • || Present address: Albert Einstein College of Medicine, Bronx, NY 10461, USA.

  • Present address: New York University, New York, NY 10016, USA.

  • # Present address: Thermo Fisher Scientific, Eindhoven, Netherlands.

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