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Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation

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Science Advances  08 Apr 2020:
Vol. 6, no. 15, eaax2746
DOI: 10.1126/sciadv.aax2746

Article Information

vol. 6 no. 15

Online ISSN: 
History: 
  • Received for publication March 8, 2019
  • Accepted for publication January 15, 2020
  • .

Author Information

  1. Roberto Ravasio1,
  2. Elena Ceccacci1,*,
  3. Luciano Nicosia1,*,
  4. Amir Hosseini1,
  5. Pier Luigi Rossi1,
  6. Iros Barozzi2,
  7. Lorenzo Fornasari1,3,
  8. Roberto Dal Zuffo4,
  9. Sergio Valente5,
  10. Rossella Fioravanti5,
  11. Ciro Mercurio4,
  12. Mario Varasi4,
  13. Andrea Mattevi6,
  14. Antonello Mai5,
  15. Giulio Pavesi7,
  16. Tiziana Bonaldi1 and
  17. Saverio Minucci1,7,8,
  1. 1Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  2. 2Department of Surgery and Cancer, Imperial College London, Hammersmith, London W12, UK.
  3. 3EryDel SpA, Via Meucci 3, 20091 Bresso (MI), Italy.
  4. 4Experimental Therapeutics Program, FIRC Institute of Molecular Oncology Foundation (IFOM), Via Adamello 16, Milan 20139, Italy.
  5. 5Department of Drug Chemistry and Technologies, Pasteur Institute Italy, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
  6. 6Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.
  7. 7Department of Biosciences, University of Milan, Milan 20133, Italy.
  8. 8New Drugs Program, European Institute of Oncology (IEO), IRCCS, Milan 20139, Italy.
  1. Corresponding author. Email: saverio.minucci{at}ieo.it
  • * These authors contributed equally to this work.

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