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Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

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Science Advances  08 Apr 2020:
Vol. 6, no. 15, eaaz4232
DOI: 10.1126/sciadv.aaz4232

Article Information

vol. 6 no. 15

Online ISSN: 
  • Received for publication September 8, 2019
  • Accepted for publication January 14, 2020
  • .

Author Information

  1. Hanna Hayat1,
  2. Noa Regev1,
  3. Noa Matosevich2,
  4. Anna Sales3,
  5. Elena Paredes-Rodriguez3,4,5,
  6. Aaron J. Krom1,6,
  7. Lottem Bergman1,
  8. Yong Li3,
  9. Marina Lavigne7,
  10. Eric J. Kremer7,
  11. Ofer Yizhar8,
  12. Anthony E. Pickering3,9 and
  13. Yuval Nir1,2,10,*
  1. 1Department Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  2. 2Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  3. 3School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK.
  4. 4Department of Pharmacology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
  5. 5Neurodegenerative Diseases Group, Biocruces-Bizkaia Health Research Institute, 48903 Barakaldo, Spain.
  6. 6Department of Anesthesiology and Critical Care Medicine, Hadassah-Hebrew University Medical Center, Hebrew University–Hadassah School of Medicine, Jerusalem, Israel.
  7. 7Institute de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS, Montpellier, France.
  8. 8Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.
  9. 9Department of Anaesthesia, University Hospitals Bristol, Bristol BS2 8HW, UK.
  10. 10Functional Neurophysiology and Sleep Research Laboratory, Tel-Aviv Sourasky Medical Center, Tel Aviv 64239, Israel.
  1. *Corresponding author. Email: yuvalnir.tau{at}


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