Cooperativity of Kv7.4 channels confers ultrafast electromechanical sensitivity and emergent properties in cochlear outer hair cells

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Science Advances  08 Apr 2020:
Vol. 6, no. 15, eaba1104
DOI: 10.1126/sciadv.aba1104

Article Information

vol. 6 no. 15

Online ISSN: 
  • Received for publication November 5, 2019
  • Accepted for publication January 14, 2020
  • .

Author Information

  1. Maria C. Perez-Flores1,*,
  2. Jeong H. Lee1,*,
  3. Seojin Park1,
  4. Xiao-Dong Zhang2,3,
  5. Choong-Ryoul Sihn1,
  6. Hannah A. Ledford2,
  7. Wenying Wang1,
  8. Hyo Jeong Kim1,
  9. Valeriy Timofeyev2,3,
  10. Vladimir Yarov-Yarovoy4,
  11. Nipavan Chiamvimonvat2,3,
  12. Richard D. Rabbitt5, and
  13. Ebenezer N. Yamoah1,
  1. 1Department of Physiology, School of Medicine, University of Nevada, Reno, Reno, NV 89557, USA.
  2. 2Department of Internal Medicine, Division of Cardiology, University of California, Davis, Davis, CA 95616, USA.
  3. 3Department of Veterans Affairs, Northern California Health Care System, Mather, CA 95655, USA.
  4. 4Department of Physiology and Membrane Biology, University of California, Davis, Davis, CA 95616, USA.
  5. 5Departments of Biomedical Engineering, Otolaryngology, and Neuroscience Program, University of Utah, Salt Lake City, UT 84112, USA.
  1. Corresponding author. Email: enyamoah{at} (E.N.Y.); r.rabbitt{at} (R.D.R.)
  • * These authors contributed equally to this work.


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