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Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease

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Science Advances  15 Apr 2020:
Vol. 6, no. 16, eaaz2387
DOI: 10.1126/sciadv.aaz2387

Article Information

vol. 6 no. 16

Online ISSN: 
History: 
  • Received for publication August 23, 2019
  • Accepted for publication January 22, 2020
  • .

Author Information

  1. Niklas Mattsson-Carlgren1,2,3,*,
  2. Emelie Andersson1,
  3. Shorena Janelidze1,
  4. Rik Ossenkoppele1,4,
  5. Philip Insel1,
  6. Olof Strandberg1,
  7. Henrik Zetterberg5,6,7,8,
  8. Howard J. Rosen9,
  9. Gil Rabinovici9,
  10. Xiyun Chai10,
  11. Kaj Blennow5,6,
  12. Jeffrey L. Dage10,
  13. Erik Stomrud1,
  14. Ruben Smith1,2,
  15. Sebastian Palmqvist1,2 and
  16. Oskar Hansson1,11,*
  1. 1Clinical Memory Research Unit, Faculty of Medicine, Lund University, Lund, Sweden.
  2. 2Department of Neurology, Skåne University Hospital, Lund University, Lund, Sweden.
  3. 3Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
  4. 4VU University Medical Center, Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, Amsterdam, Netherlands.
  5. 5Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.
  6. 6Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
  7. 7Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
  8. 8UK Dementia Research Institute, London, UK.
  9. 9Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.
  10. 10Eli Lilly and Company, Indianapolis, IN, USA.
  11. 11Memory Clinic, Skåne University Hospital, Malmö, Sweden.
  1. *Corresponding author. Email: niklas.mattsson{at}med.lu.se (N.M-.C.); oskar.hansson{at}med.lu.se (O.H.)

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