Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing

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Science Advances  15 Apr 2020:
Vol. 6, no. 16, eaba0694
DOI: 10.1126/sciadv.aba0694

Article Information

vol. 6 no. 16

Online ISSN: 
  • Received for publication November 1, 2019
  • Accepted for publication January 22, 2020
  • .

Author Information

  1. Natascha Sommer1,
  2. Nasim Alebrahimdehkordi1,
  3. Oleg Pak1,
  4. Fenja Knoepp1,
  5. Ievgen Strielkov1,
  6. Susan Scheibe1,
  7. Eric Dufour2,
  8. Ana Andjelković2,
  9. Akylbek Sydykov1,
  10. Alireza Saraji1,
  11. Aleksandar Petrovic1,
  12. Karin Quanz1,
  13. Matthias Hecker1,
  14. Manish Kumar1,
  15. Joel Wahl3,
  16. Simone Kraut1,
  17. Werner Seeger1,
  18. Ralph T. Schermuly1,
  19. Hossein A. Ghofrani1,4,
  20. Kerstin Ramser3,
  21. Thomas Braun5,
  22. Howard T. Jacobs2,
  23. Norbert Weissmann1,* and
  24. Marten Szibor2,*,
  1. 1Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany.
  2. 2Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland.
  3. 3Department of Engineering Sciences and Mathematics, Luleå University of Technology, SE-97187 Luleå, Sweden.
  4. 4Department of Medicine, Imperial College London, Du Cane Road, Hammersmith Campus, London W12 0NN, UK.
  5. 5Department I, Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany.
  1. *Corresponding author. Email: marten.szibor{at} (M.S.); norbert.weissmann{at} (N.W.)
  • Present address: Department of Cardiothoracic Surgery, Jena University Hospital, D-07747 Jena, Germany.


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